Dr. Dominic D’Agostino on Everything You Need to Know About Keto

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Hello, and welcome to the “Valence Mama Podcast”. I’m Katie at valentinsma.com, and this event is all you need to know about ketogenic food and everything that goes with it, including whether it is safe for women or not, its practical applications, To be doing exactly what you are, and what emerging research says about that. I am here with a top expert in the world whose research I have followed for a long time, and it is an honor to talk to him.

Dr. Dominic Dagostino is Professor of Molecular Pharmacology and Physiology at the University of South Florida and a Research Scientist at IHMC’s Institute for Human and Machine Cognition. Its laboratory develops and tests metabolic strategies to enhance the safety and flexibility of military personnel in neurological disorders, cancers, and extreme environments. He was both a researcher and a contributor to NASA’s Nemo Project, and his research is supported by the Office of Naval Research, the Department of Defense, private organizations and foundations, and many of us who value his work.

And I’m going to talk about this phenomenon for a while, but when it comes to health, it’s a lot of walking. In fact, he broke the world record of being the heaviest weightlifter in 24 hours, and he also lifted a dead weight of 500 pounds in the seventh fast. So he is an incredible human being, intellectually and physically, and it is an honor to be involved with him today. So, without further ado, let’s jump in with Dr. D’Agostino.

Katie: Dom, I’m excited to chat with you. If what I read is true, then you broke the world record by sitting at the highest weight in 24 hours and lifting 500 pounds after a week of fasting. Which is amazing to me. And I have fasted for several days but I never tried to work in the last days. When it comes to health, you are clearly on foot. You are known for your research into the ketogenic diet and I want to delve deeper into today’s practical and scientific application. So in order to expand and then narrow, there are some emerging ketogenic diet applications that you are looking for in your research.

Dr. Dominick: Yes, so the ketogenic diet started 100 years ago as a medical therapy for epilepsy, and many people don’t know. But over the past decade, the use of dietary ketosis has been widely applied for disorders including a variety of neurological disorders, metabolic disorders, and even psychiatric disorders. In our lab, we study a lot of things. I would say that half of what we do is cancer research, and we do it at the Moffat Cancer Institute. It is the largest cancer treatment center near the University of South Florida. It is its own separate entity. But I would say that in our lab, it is probably one of the biggest emerging applications and possibly the more controversial application of nutrition ketosis to treat serious and complex things like cancer food as medicine. To be used.

And when I entered this field, there were probably two clinical trials on clinical trials registered on ClinicalTrials.gov, and now there are about 38 or 39 clinical trials that I think of as therapy for cancer treatment. Was examined using a ketogenic diet. Most cases serve as a supplement to further enhance or enhance different forms of therapy. And in some cases when the quality of care fails, a ketogenic diet is used. So we have studied in the past several animal models of Alzheimer’s disease and Alzheimer’s disease, and we are in fact doing the largest project in the lab to develop a ketogenic mechanism for dietary ketosis or extra ketosis. Which delays seizures of oxygen toxins that limit the navy cell. Operations because they use a closed breathing circuit again in their secret tasks.

So what we do is with the different technologies we have in the lab, we can count on what the Navy Seal will experience in certain terms. And then we test everything from the cell point of view to the tissues, we have used different animal samples, and right now we have human clinical trials at Duke University where we submerge the articles inside them and Push the edge of the occupation. And beyond ketosis, this is like our main plan. We have many pet projects, such as targeting glucose control, which have implications for type 2 diabetes, which I think is a major emerging application of dietary ketosis.

Katie: It’s very interesting. And before we go any further, I’d like to tell you what your ketogenic diet is because there are thousands of different definitions and recipes going on here. So what definition are we using for this podcast?

Dr. Dominick: Yes, I think part of the problem is that nutritional ketosis is a term that people sell in various markets to supplement food, which is basically candy bars. The ketogenic diet is the only diet to my knowledge that is specifically explained by bio-marker elevations that we can actually measure with commercially available technology. And you can buy a blood ketone meter from a CVS or a Walgreens or you can buy one on Amazon. You can find it at Walmart. These devices will usually measure blood glucose and will also measure the ketone body beta hydroxybutyrate. So if you decide on a ketogenic diet or medical management, you know, whether it is epilepsy, which was the original application, or weight loss, which is a really popular application on the ketogenic diet for type 2 diabetes, In fact, the last five years have been very well documented.

You can go to the drugstore or online and buy a blood ketone meter and implement it, start a ketogenic diet. There are so many different… there are tons of resources online that didn’t exist when I started studying them over a decade ago. And they tell you how to put food together for a ketogenic diet, you know, grow, you know, there are recipes for that. So you can start a ketogenic diet and monitor your blood ketone levels, and it can help guide you on how to prepare your diet from a variety of foods and protein to carbohydrate ratio. , And it’s really the macronut ratio. Which explains the ketogenic diet.

We know that if we eat a certain proportion or fat from carbohydrate to protein, the fat level must be between 90 to 65 fat and the protein level is usually between 10 to 25 or 30. In which carbohydrates are limited to 10 restricted. Or non-starch, non-sugar, down to fiber carbohydrates that basically have very low glycemic index. When a diet is prepared in this way, it depends on the individual and on the proportion that will cause some degree of ketosis.

Katie: That makes sense. Therefore some versions of the ketogenic diet may be considered unhealthy. Are there things you can take care of or avoid while trying out a keto diet?

Dr. Dominic: Yes, of course you know a lot, there is a readymade ketogenic meal in the market There are many recipes that claim to be ketogenic and may contain low carbohydrate content but they deviate from what I would call a clinical ketogenic diet. And to get the full benefits of dietary ketosis, an individual usually has to raise their blood ketone levels within a range that is characteristic of dietary ketosis. And a little confused and I think people are using the term ketogenic diet and they are marketing a really low carbohydrate diet, which has a lot of benefits in terms of controlling your blood glucose, Maybe weight loss, an appetite suppressing effect.

Many people believe that a high protein diet is a ketogenic diet and is not really so because if you eat too much protein, protein can turn into glucose and it can also stimulate the hormone insulin. And it can put you out of ketosis, or basically prevent you from producing ketone bodies, which we know are beneficial to our brains and our hearts and many other organs. And this is the level of ketones that is a sign of suppressing the hormone insulin. And once you stabilize and lower the hormone insulin, it puts your body in a fat burning mode and is supposed to burn more fat, which is really helpful in high ketones.

So your ketones are, in fact, like a surrogate marker that can estimate how much body fat you are burning. And I think, from a general point of view, many people are interested in a ketogenic diet for weight loss. And so I think diet ketosis monitoring, which is basically a very effective tool to tell this person how to burn fat for energy and their body fat. When they restrict calories overall, they will be free, you know, they have fat in their own body but it is also a mixture of dietary fat because you are also eating more fat. So it’s making ketos, but when you restrict total calories, which makes it easier to eat on a ketogenic diet because of the suppressive effect and that has a huge benefit, you can actually increase your Also taps into fat stores.

Katie: That makes sense. Is there an ideal range for ketones in something like Vital Oils and is it different from ketone levels in something like cancer?

Dr. Dominick: Yes, that’s a good question. And we don’t really know all the answers, but, in general, if your blood tunes are anywhere between 0.8, than your responses … if you are above 0.5 mm, and this small meter is larger If so, it will also be represented as mmol liters, millimeters per milliliter, and these are the units you typically measure in these devices. If your level is above 0.5, you are in a state of ketosis clinically and it is difficult to achieve, that it is difficult to eat a standard diet, if not impossible, you usually have to fast, you know. Yes, it takes about 18 to 24 hours for your ketones to reach this level. So if you can create a diet where you have ketosis 0.5 to 3 or 4 mm in maximum condition, I believe it is like a maximum level.

If I live between 1 and 2 mm linear ketones, I feel like I have the most energy, have a lot of mental clarity, my inflammation is the lowest and if my ketones are a bit high If so, I usually have to do the things I have to do to follow a diet that is more restrictive to carbohydrates. And I think it’s best to have some carbohydrates in your diet, such as a little beer, vegetables, and, you know, a little dark chocolate every day. So you can get these things on a ketogenic diet. The more carbohydrates you put into it can knock you down, but the more you experiment with diet, the more you start to realize how much you can increase. And I think some of them have many benefits, you know, plant foods and I want to include some of them in the diet.

And some ketogenic diets completely eliminate it. And I know carnivorous food has been a huge thing and many people support it and I’m not entirely sure that this diet is really better than a well-prepared ketogenic diet that will contain vegetables. A lot of people with autoimmune diseases, you know, whether they have skin diseases or things like Hashimo’s disease or other things emailed me and basically said that a ketogenic diet from plants Not to be outdone, it has only been the keto carnivorous diet that has worked to overcome their auto-malfunction. So I think people need to consider this and it’s not just a study.

In Hungary there is a group called palliomedicina and they are treated like thousands of patients with autoimmune diseases and everything from epilepsy to cancer is combined with a stroke ketogenic diet and we recently visited Hungary. And have seen some patient records. And I have to admit, you know, a stroke ketogenic diet, which is basically just about all animal products and no vegetables, is very useful for some autoimmune disorders. But from my point of view, I’m still not completely sold as someone who just wants to implement a ketogenic diet as a lifestyle. I think it would be ideal to include a balanced balanced ketogenic diet that includes vegetables and fruits. At least I think it’s for me.

Katie: What does it look like? Based on your experience, what would you consider to be the best version of the Keto Diet and what can it do with less saturated fat? I ask because I have the APOE4 gene, and so I’m careful to eat saturated fat. And I want to lean towards mono-unsaturated fat. So can you do ketosis without saturated fat?

Dr. Dominick: Yes, this is a really good question and one I get asked often. Yes, you can definitely eat a ketogenic diet that is low in saturated fat. So what you really want to do in this case is get as much fat as possible. And one way to do this is to maybe restrict dairy as the main source of saturated fat in the ketogenic diet is dairy. The initial ketogenic diet developed by the Mayo Clinic and Johns Hopkins was almost a dairy-based ketogenic diet because it made it flexible for children. They can get the calories they need for growth. But a kegenic diet that is low in saturated fat will include things like eggs. The fat in the eggs is mostly oleic acid so it is high in fat. So, you know, eggs and fish and nuts and nuts, olive oil is a must.

And then you want to … you know, if you have APOE4 you say okay, saturated fat is something you might worry about. It helps with factors that can negatively impact your results. But science is kind of unclear. So a dairy-based high-dose ketogenic diet like fish, eggs, and my opinion is that the steak is fine even though it contains saturated fat, but you know this steak is from grass-fed animals. Pork and chicken may also be fine. But from my point of view, and I followed a dairy-based ketogenic diet when I started this 12 years ago and some of my markers got really different parts of LDL and I was a little worried. And I minimized the dairy in this way. At a certain level I am still in it and I have milk every day, but I have significantly reduced it and filled the gap, the main difference from most fat-derived fat, which is more Fat is more monosaturated and makes a big difference.

So just like today, for example, I don’t always do that, but I skipped breakfast and ate my first meal around noon, which was salmon, and I experimented with different products that people send me. The almonds were made from flour and they were a little bit sweet, and it was like my first meal. And all that kind of thing I ate today. And then tonight we have grass fed beef by a company called Butcher Box, which sells only grass fed beef. This is a service that we subscribe to. They have the best selection of meat. And usually a salad and, you know, cabbage broth or broccoli or something. ہمارے پاس عام طور پر رات کے کھانے کے لئے کچھ قسم کا گائے کا گوشت ، مچھلی ، اور سبزی ہوتی ہے اور اس میں ہمیشہ تھوڑی مقدار میں چربی والی سلاد ہوتی ہے۔

کیٹی: سمجھ گیا اس بارے میں بھی بہت رائے ہے ، لیکن کبھی کبھار کارب ریفڈ کرنے کی کیا ضرورت ہے یا اگر لوگوں کو جسم میں کاربس نہ لگانے سے ڈھالنے سے روکنے کے لئے ایک بار تھوڑا سا کھا جانا چاہئے ، تو کیا آپ ایسا کریں گے اور تحقیق کیا کہتی ہے؟

ڈاکٹر ڈومینک: ہاں ، میں سمجھتا ہوں کہ لوگوں کو واقعتا experiment تجربہ کرنے کی ضرورت ہے کہ غذا کا بہتر استعمال کیا ہو۔ اور آپ جانتے ہو ، میں کیٹوجینک غذا یا تغذیہ بخش کیتوسیس کا وکیل ہوں ، اس کا مطلب بہت سے چیزوں کے لئے ضمنی کیٹٹوس بھی ہوسکتا ہے۔ اور اگر ، آپ جانتے ہو ، ثقافتی وجوہات کی بناء پر اور لوگوں کے جسم کی مختلف اقسام میں طرح طرح کے تحول ہوتے ہیں ، جہاں ہر شخص کی طرح انفرادی میٹابولک ہستی کی طرح ہوتا ہے اور کیٹجینک غذا سے وابستہ مختلف کھانے کے انتخاب ، وہ برداشت نہیں کرسکتے ہیں۔ اور میں نے ان لوگوں سے ملاقات کی ہے جو کیٹوجینک غذا سے وابستہ چربی کے مواد کو برداشت نہیں کرسکتے ہیں۔ لیکن ذاتی طور پر میرے لئے ، میں بہتر محسوس کرتا ہوں اور میں اپنا بہترین کام کرتا ہوں ، خواہ وہ لکھنا ہو یا محض ، آپ جانتے ہو ، علمی کام ، اور یہاں تک کہ جسمانی طور پر بھی ، میں کچھ حد تک کیٹوسیس میں بہتر محسوس کرتا ہوں اور نہیں… میں نہیں کرتا ٹی میڈیکل کیتوجنک ڈائیٹ کی سطح پر عمل پیرا ہوتا ہے ، جو کہیں بھی اسی طرح ہوتا ہے جیسے 80٪ سے 90٪ چربی ہوتی ہے ، لیکن میں عام طور پر کہیں 60٪ چربی کے ارد گرد ہوتا ہوں۔

اور بالکل ایک مثال کے طور پر ، کل میرے پاس شاید معمول سے تھوڑا سا کاربوہائیڈریٹ تھا۔ ہمارے پاس ہماری پراپرٹی پر پھل دار درخت ہیں لہذا میں نے رات کے وقت انگور کا پھل لگایا تھا اور میرے پاس کچھ بلوبیری اور ایک بہت بڑا ترکاریاں تھا اور کچھ بھون سبزیوں کو بھی بھڑکاتے ہیں اور ایک یا دو گہرے چاکلیٹ کی طرح۔ لہذا کل کے لئے میرا کاربوہائیڈریٹ شاید تقریبا probably 100 گرام کاربس تھا اور شاید اس میں سے ایک تہائی فائبر تھا اور میں ابھی بھی ہلکی کیٹوسس کی حالت میں تھا کیونکہ میں دن بھر کی طرح کافی سرگرم تھا۔ اور اب ، یہ سب کے ل. معاملہ نہیں ہوسکتا ہے۔ میں کچھ بچوں کو جانتا ہوں جو مرگی یا دیگر چیزوں کے لئے کیٹٹوجینک غذا کی پیروی کرتے ہیں ، ان میں کاربوہائیڈریٹ کی مقدار ہوسکتی ہے شاید سارا دن ایک اسٹرابیری کی طرح ہوتا ہے۔ اسٹرابیری میں فائبر بہت زیادہ ہوتا ہے ، جیسے آپ جانتے ہو ، گلیسیمک کم سے کم ردعمل ہے۔

لیکن میں بہت سے مختلف والدین سے رابطے میں ہوں ، میں نے دیکھا ہے ، آپ جانتے ہوں گے ، سیکڑوں نہیں اگر ہزاروں غذائی منصوبے ہوں اور میں نے بچوں سے بڑوں تک مختلف لوگوں کے خون کی سطح دیکھی ہے اور مجھے یہ کہنا پڑتا ہے کہ بہت کچھ ہے تغیر کی اور میں نے کچھ ایلیٹ لیول اولمپک ایتھلیٹوں کے ساتھ بھی بات چیت کی ہے جو غذائیت کیٹوسیس کی پیروی کرتے ہیں اور وہ ایک دن میں تقریبا 200 سے 250 گرام کاربوہائیڈریٹ کھاتے ہوئے کیٹٹوس کی حالت میں رہ سکتے ہیں ، لیکن وہ دن میں چار سے چھ گھنٹے کی طرح ورزش بھی کر رہے ہیں۔ اور وہ شاید ایک حرارت خسارے میں ہیں۔ لہذا آپ کو اس میں بہت زیادہ غلو ہے اور یہ واقعی میں کھانے کی ترجیحات پر آتا ہے۔

لہذا یہ معلوم کریں کہ آپ کس طرح کا کھانا پسند کرتے ہیں اور ان میں سے زیادہ سے زیادہ کھانے کو شامل کرتے ہیں اور یہ ہوسکتا ہے… آپ جانتے ہو ، عام طور پر زیادہ تر لوگ جیسے مچھلی اور مرغی اور گائے کا گوشت اور سور کا گوشت ، اور انڈے پسند کرتے ہیں۔ اور اگر آپ بیک کررہے ہیں تو ، آپ مختلف قسم کے فلور استعمال کرسکتے ہیں جو اب مارکیٹ میں ہیں۔ ان میں سے کچھ نٹ فرور ہیں اور آپ مفنز اور کیک بناسکتے ہیں ، اور ہم کبھی کبھار اپنے گھر میں پینکیکس بناتے ہیں۔ لہذا آپ کو راحت والے کھانے بھی مل سکتے ہیں۔ اور بہت سارے کاروباری افراد واقعی اس جگہ میں داخل ہونے کے لئے گھس رہے ہیں اور وہ کم کارب کیتوجینک بھوری سے لے کر کوکیز ، ہیمبرگر بنس ، باربی کیو ساس تک سب کچھ تیار کررہے ہیں۔ میرا مطلب ہے ، بہت ساری مختلف مصنوعات ہیں۔

ہم نے کچھ ہفتوں پہلے کی طرح میٹابولک ہیلتھ سمٹ کی میزبانی کی تھی اور اس جگہ میں اسٹیک ہولڈرز کی مقدار تیزی سے بڑھ رہی ہے ، اور یہ علمی طب سے لے کر کلینیکل میڈیسن ، انڈسٹری ، میڈیا ، صرف عام لوگوں تک ہے۔ لہذا یہ جگہ کافی تیزی سے بڑھ رہی ہے اور ان میں سے بہت ساری کمپنیاں ایسی مصنوعات تیار کررہی ہیں جو واقعی میں اس کمیونٹی کی خدمت کر رہی ہیں جس میں مجھے نیٹ ورک کیا گیا ہے۔ اور اس میں مرگی برادری بھی شامل ہے ، جو اس غذا کی طرح ہے جس کے لئے اس کا بہت اچھا ٹریک ریکارڈ ہے ، اور ان دیگر ابھرتی ہوئی ایپلی کیشنز کی ایک بڑی تعداد ، قسم 2 ذیابیطس ان میں سے ایک ہے۔

اور بہت ساری چیزیں ہیں… آپ جانتے ہو ، ایک کیٹجینک غذا نہیں۔ یہ ایک سائز میں بالکل فٹ نہیں ہوتا ہے جب آپ کسی کیٹجنک غذا کے بارے میں مطالعہ پڑھتے ہیں تو اس نے مثبت اثر یا منفی اثر یا کوئی اثر نہیں نکالا ، سب سے اہم بات یہ ہے کہ اس بات کا پتہ لگانا ہے کہ اس تحقیق میں کس طرح کیٹوجینک غذا کا استعمال کیا گیا ہے۔ میرا مطلب ہے ، کیٹٹوجینک غذا کی لامحدود مقدار ہے۔ ابتدائی کیٹجنک غذائیں زیادہ تر ہائیڈروجنیٹڈ چربی پر مبنی تھیں ، یقین کریں یا نہ کریں ، یا کرسکو بھی۔ اور ہم صرف یہ کہتے ہیں کہ ، اب ہم تغذیہ کے بارے میں بہت کچھ جانتے ہیں اور مجھے یقین ہے کہ ایسی کیٹجنک غذا وضع کرنے کے طریقے موجود ہیں جو ہر ایک کے لئے صحت مند ثابت ہوسکتے ہیں لیکن یہ آپ کے غذا کی ترجیحات پر منحصر ہر فرد کے ل be نہیں ہوسکتا ہے۔

کیٹی: تو ایکسجنسی زون کا کیا ہوگا؟ یہ ایسی چیز ہے جس کا میں نے ذاتی طور پر تجربہ نہیں کیا ہے لیکن حقیقت میں اب کچھ میرے پاس ان کے پاس جا رہے ہیں اور میں واقعتا اس کے بارے میں دلچسپ ہوں اور میں جانتا ہوں کہ آپ نے اس پر کچھ تحقیق کی ہے۔ تو کیٹو ڈائیٹ میں ایکسجنسی زون کا کیا کردار ہے اور ہمیں اس کے استعمال کے بارے میں کیا جاننے کی ضرورت ہے؟

ڈاکٹر ڈومینک: ہاں ، شاید یہی وجہ ہے کہ میں جانتا ہوں کیونکہ جب میں نے پہلی بار کیٹوجینک غذا کا مطالعہ کرنا شروع کیا تو ، میرا مقصد یہ تھا کہ آکسیجن زہریلا کے دوروں کے لئے کیٹوجینک غذا کا استعمال کیا جائے ، جو ایک فوجی مسئلے کی طرح ہے۔ اس وقت فوج میں موجود پروگرام آفیسر کو کسی کو زیادہ چکنائی والی ketogenic غذا لگانے کا خیال پسند نہیں تھا۔ یہ بہت پابند تھا اور وہ جانتے تھے کہ لوگ ایسا نہیں کریں گے۔ تو انہوں نے مجھ سے گولی میں ایک طرح کیٹجینک غذا تیار کرنے کو کہا۔ بہت سال پہلے ، آپ جانتے ہو ، میں نے مختلف حکمت عملیوں کو تیار کرنا شروع کیا اور حکمت عملی میں سے ایک کیٹون ایسٹر اور کیٹون معدنی نمکیات کی نشوونما ہوگی ، جو بنیادی طور پر ایک کیٹون جسم لے رہی ہے جس کو آپ کا جسم قدرتی طور پر بناتا ہے ، جیسے بایویڈیٹیکل انو ، اور پھر اس کو یکجا کرکے سوڈیم ، پوٹاشیم ، یا میگنیشیم جیسے الیکٹرولائٹ کے ساتھ۔

اور پھر آپ واقعی میں ان چیزوں کو لیبارٹری میں بنا سکتے ہیں اور اس میں سے ایک پاؤڈر تیار کرسکتے ہیں اور پھر آپ اسے زبانی طور پر کسی شیک یا ڈرنک میں کھا سکتے ہیں اور یہ آپ کے کیٹون کی سطح کو بڑھا سکتا ہے۔ بیٹا ہائیڈرو آکسیبیوٹیریٹ وہی ہے جس کو ہم ایک میٹر کے ساتھ ماپتے ہیں۔ اور پھر وہ طبی لحاظ سے غذائیت کی کیفیت ہے یا جسے ہم علاج معالج کہتے ہیں۔ لہذا یہ خون میں توانائی کے انو کو بلند کررہا ہے جس کی طرح ایک اعلی توانائی بخش قدر ہے۔ اگر آپ کا جسم زیادہ سے زیادہ اے ٹی پی بنا سکتا ہے ، جو ہمارے خلیوں کے ذریعہ استعمال ہونے والی توانائی کرنسی ہے تو ، یہ کیٹوز کے ذریعہ اے ٹی پی کو زیادہ موثر بنا سکتا ہے۔ اور ہم یہ بھی جانتے ہیں کہ ان کیٹون جسموں میں ہارمون جیسا اثر ہوتا ہے اور ان کا سگما [SP] انو جو خاص راستوں پر اثر انداز ہوسکتے ہیں ، مثال کے طور پر سوزش۔ وہ جسم میں سوجن ، جیسے ، کی سطح کو دبا سکتے ہیں۔

لہذا مارکیٹ میں بہت ساری مختلف قسم کے خارجی کیتونز ہیں۔ ہم ان کی جانچ کرتے ہیں لیکن ، آپ جانتے ہو ، ہم ان کو فروخت نہیں کرتے ہیں۔ میں سمجھتا ہوں کہ کچھ لوگ بازار میں ایسی چیزیں لیتے ہیں جیسے میری ضمیمہ۔ تو صرف ریکارڈ کے لئے ، میرے پاس خود کوئی کیٹون سپلیمنٹ نہیں ہے۔ ہم مختلف پیٹنٹ تیار کرتے ہیں اور کچھ کمپنیوں نے ان پیٹنٹ کو حاصل کرلیا ہے۔ میں مارکیٹ میں موجود کیتون مصنوعات کی جانچ کرنا چاہتا ہوں اگر میں جانتا ہوں کہ وہ محفوظ ہیں اور کسی مشہور کمپنی سے ہیں۔ اور پھر ان میں سے کچھ پروڈکٹ جن کی میں نے ویب سائٹ ، ketonutrition.org پر رکھی ہے ، صرف لوگوں کو ایسی مشہور کمپنیوں کی طرف راغب کرنے کے لئے جو کمٹون ضمیمہ کی مصنوعات بنا رہی ہیں جن کے پاس تجزیہ کا کم از کم ایک بہت اچھا سند ہے جو صاف مصنوعات ہیں جو حقیقت میں آپ کو بلند کردیں گی ketone کی سطح کم یا زیادہ۔

لہذا ان سپلیمنٹس کے فوائد یہ ہیں کہ جب آپ ان کا استعمال کرتے ہیں تو ، وہ آپ کے جسم کو توانائی فراہم کرسکتے ہیں اور میں انہیں صرف ایک ketogenic کھانے کے طور پر دیکھتا ہوں۔ وہ کیلوری پر مشتمل غذائی سپلیمنٹس ہیں جو جب آپ ان کو کیٹوجینک غذا کے ساتھ کھاتے ہیں تو ، وہ آپ کے کیتون کو مزید بلند کرسکتے ہیں اور شاید کیٹوجینک غذا کے علاج معالجہ کو مزید بڑھا سکتے ہیں۔ اب ، کچھ ایسے حالات ہیں جہاں کوئی کیٹوجینک غذا کی پیروی کرنے کے لئے راضی نہیں ہے یا اس سے قاصر ہے۔ مثال کے طور پر ، کچھ خرابی کی شکایت جن کا ہم لیب میں مطالعہ کرتے ہیں ، آپ جانتے ہو ، مختلف امراض جیسے بچے انجل مین سنڈروم یا آٹزم یا کبوکی سنڈروم۔ یہ ایک اور چیز ہے۔

اور مجھے سمجھانے کی ضرورت نہیں ہے ، آپ جانتے ہیں کہ یہ عوارض لیکن جن بچوں میں کچھ خرابیاں ہیں ، ان کے ل certain کچھ خاص قسم کی غذاوں پر عمل کرنا مشکل ہے۔ لہذا ایک کیٹون ضمیمہ جو وضع کیا گیا ہے ، اور ذائقہ دار ایجنٹ اس کو اچھا ذائقہ بناسکتے ہیں ، ان عوارض میں مبتلا بچوں کو بہت زیادہ فائدہ پیش کرسکتے ہیں۔ اور آپ ان امراض کو نشانہ بنانا چاہتے ہیں جہاں کیٹوجینک غذا پہلے ہی موثر ثابت ہوئی ہو ، جہاں کلینیکل ٹرائلز اور شائع شدہ مطالعات کا اشتراک کرنا ہو ، مثال کے طور پر ، کہ کیٹوجینک غذا گلوکوز ٹرانسپورٹر کی کمی سنڈروم کا علاج کر سکتی ہے ، جس کا ہم مطالعہ کرتے ہیں۔

لہذا ، بہت سے بچے ، انہیں اس غذا پر عمل کرنا مشکل محسوس ہوتا ہے۔ لہذا ایک ضمیمہ جو کیٹوز کو بلند کرتا ہے ، جو علاج معالجہ ہے جو ان افراد کی مدد کرسکتا ہے جن میں گلوکوز ٹرانسپورٹر کی کمی ہے ، یہ ضمیمہ واقعی قریب قریب ہوسکتا ہے ، میں جادوئی گولی نہیں کہنے والا ہوں ، لیکن یہ علاج معالجہ ہوسکتا ہے جس کو سنبھالنے میں مدد مل سکے۔ خاص طور پر میٹابولک ڈس آرڈر۔ اور یہی وہ جگہ ہے جہاں ہم واقعی اپنی توانائی اور وقت اور کوشش کی بہتات کو نہ صرف ان کیٹون سپلیمنٹس کے فوجی استعمال پر کام کرنے کی ہدایت کرتے ہیں بلکہ اس سائنس کو ایسی چیزوں کو تیار کرنے کے لئے استعمال کرتے ہیں جو کلینیکل فیلڈ میں بھی استعمال ہوسکتی ہیں۔ اور ہمارے پاس ایک مطالعہ ہے ، وانڈربلٹ یونیورسٹی میں ایک جاری مطالعہ ہے جس میں انجل مین سنڈروم کے لئے کیٹون ضمیمہ استعمال کیا جاتا ہے ، جو ایک نادر جینیاتی عارضہ ہے جو صرف کیٹوجینک غذا کے لئے جواب دہ ہوتا ہے۔ لہذا ابھی انجیل مین سنڈروم والے بچوں میں کیٹوسن سپلیمنٹس استعمال کرنے والے ایک اسٹڈی جاری ہے۔

کیٹی: یہ دلچسپ ہے۔ اور الیکٹرولائٹس کے بارے میں بات کرتے ہوئے ، کیا یہ ایسی چیز ہے جس کے بارے میں ہمیں آگاہی اور کیٹو ڈائیٹ طویل مدتی تکمیل تک پہنچانے کی ضرورت ہے ، میں جانتا ہوں کہ کچھ ذرائع ہیں کہ آپ کو زیادہ الیکٹرولائٹس کی ضرورت ہے اگر آپ کم کارب کھاتے ہیں اور کیٹو ہیں اور کیا کوئی اور سپلیمنٹس ہیں کہ ہم کے بارے میں بھی جاننا چاہئے؟

ڈاکٹر ڈومینک: ہاں ، یہ ایک اچھی بات ہے کیونکہ جب آپ صرف غذائیت سے متعلق تناسب کو ایڈجسٹ کرکے تغذیہ بخش کیتوسیس کی حالت میں ہوتے ہیں تو ، ہم جانتے ہیں کہ آپ ہارمون انسولین کو دبا رہے ہیں۔ اور جب آپ یہ کرتے ہیں تو ، آپ سوڈیم اور شاید پوٹاشیم اور میگنیشیم سمیت اس سے زیادہ پانی اور زیادہ الیکٹرولائٹس خارج کرتے ہیں ، لہذا آپ شروع میں تھوڑا سا پانی کی کمی کا شکار ہوجاتے ہیں۔ اور ایک ہی وقت میں ، بہت سارے لوگ اس سے گزرتے ہیں جسے وہ کیٹو فلو کہتے ہیں۔ اور کیٹو فلو سر درد کا تھوڑا سا محسوس کر رہا ہے ، آپ کو تھوڑا سا سستی ہوسکتی ہے ، اور آپ کو اچھا محسوس نہیں ہوتا ہے۔ یہ پانی کی کمی ہوسکتی ہے اور جسے ہم ہائپوونٹریمیا کہتے ہیں ، جس میں سوڈیم کم ہے۔ لہذا اچھ hyی طور پر ہائیڈریٹ رہنا اور حقیقت میں یہ یقینی بنانا ہے کہ آپ کو کافی سوڈیم مل رہا ہے ، جس میں سوڈیم کا ابتدائی نقصان ہے ، خاص طور پر پہلے دو یا تین ہفتوں میں۔

آپ کو لازمی طور پر الیکٹروائلیٹ سپلیمنٹس خریدنے کی ضرورت نہیں ہے۔ وہ کچھ لوگوں کی مدد کرسکتے ہیں لیکن میں جو لوگوں کو بتاتا ہوں وہ یہ ہے کہ اچھے معیار کے ہڈیوں کا شوربہ ہونا چاہئے یا اپنی ہڈی کا شوربہ بنانا ہے۔ آپ شاید اپنے کھانے میں نمک ڈالنا چاہیں ، چاہے وہ سلاد ہو یا گائے کا گوشت جو آپ کھانا بنا رہے ہیں ، اور یہ کافی سے زیادہ ہونا چاہئے۔ غذا آپ کی بھوک اور پیاس کو بھی دباتی ہے لہذا آپ اس بات کو یقینی بنانا چاہتے ہیں کہ اگر آپ کو پیاس نہ ہو کہ آپ کافی مقدار میں پانی استعمال کررہے ہیں ، خاص طور پر خوراک کے ابتدائی دو سے تین ہفتوں کے دوران کیونکہ آپ شاید تھوڑا سا پانی کی کمی کا شکار ہوجائیں اور آپ کو درد ہوسکتا ہے اور تھوڑا سا سست محسوس ہوتا ہے۔ لہذا ، آپ جانتے ہو ، پانی اور الیکٹرولائٹس حاصل کرنا پہلے چند ہفتوں کے دوران حاصل کرنا زیادہ ضروری ہے۔

کیٹی: گوٹا

یہ قسط آپ کو مکھیوں سے بچانے والے قدرتی جانور – آپ کو چھتے سے آنے والی سپر فوڈ پروڈکٹس لاتے ہیں جو آپ کے کنبہ کی صحت کی تائید میں مدد کرتی ہیں۔ ابھی ، ان کا پرپولیس ایک زندگی بچانے والا رہا ہے جہاں ہم رہتے ہیں جہاں سارے بوٹوں اور کھانسیوں کی کھانسی ہوتی ہے۔ پروپولیس ایک رالدار مرکب ہے جو شہد کی مکھیاں چھتے میں بنتا ہے اور اس میں 300 سے زیادہ مرکبات شامل ہیں جن میں پولیفینولز اور مرکبات شامل ہیں جو اینٹی بیکٹیریل ہیں اور ایک مرکب جو پیانوسیمبرین ہیں جو اینٹی فنگل کے طور پر کام کرتا ہے۔ کچھ مطالعات سے پتہ چلتا ہے کہ پروپولیس زخم کی تندرستی کو تیز کر سکتی ہے۔ یہ قدرتی اینٹی بیکٹیریل اور اینٹی فنگل خصوصیات بھی ان کو سونفوں سے لڑنے کے ل. بہترین بناتی ہے۔ کسی بھی مہکنے ، گلے کی سوزش یا کھانسی کی علامت پر ، میں گلے میں پروپولیس چھڑکتا ہوں اور یہ ہمیشہ ہماری مدد کرتا ہے کہ جلدی سے پیچھے اچھال پائے۔ ہوائی جہاز میں کسی بھی چیز کا انتخاب کرنے سے بچنے کے لئے میں پرواز سے پہلے پروپولیس کا استعمال بھی کرتا ہوں۔ آپ پروپولیس اور مکھیوں کی حفاظت کرنے والے قدرتی مصنوعات پر beekeepersn Naturals.com/wellnessmama پر کوڈ ویلنسما کے ساتھ 15 فیصد بچاسکتے ہیں۔

یہ پوڈ کاسٹ آپ کو چار سگمیٹک – سپرف فوڈ مشروم کے ل for میرا ذریعہ لاتا ہے۔ چار سگمیٹک مزیدار مشروم انفیوژنڈ ٹافیاں ، چائے اور املیسس بناتا ہے جو میں روزانہ استعمال کرتا ہوں۔ ان کے نچلے کیفین کافی اور کافی پیکٹوں سے شیروں منے کو جو میں صبح پیتا ہوں ، چاگا اور کارڈی سیپس پر توجہ مرکوز کرتا ہوں جب کہ میں کام کرتا ہوں اور ریشی رات کو نیچے آکر گروں… یہ مصنوعات میرے معمول کا ایک باقاعدہ حصہ ہیں۔ یہاں ایک نوکیا ہے… مجھے معلوم ہوا ہے کہ گہری نیند کے لئے ، ریشی کا ایک پیکٹ جس میں مکادیمیا دودھ کا ایک چھڑکاؤ ہے اور نمک کی ایک چھوٹی سی چھڑکی اور اسٹیویا کی ایک قطرہ مجھے زیادہ گہری نیند لینے میں مدد دیتی ہے اور میں نے اسے مستقل طور پر اور پیمائش کے ساتھ دیکھا ہے۔ میری نیند سے باخبر رہنا۔ اس پوڈ کاسٹ کے سننے والے کی حیثیت سے ، آپ فورسیگمیٹک / ویلنسمااما پر جاکر اور کوڈ “ویلینسما” کا استعمال کرکے 15٪ کی بچت کرسکتے ہیں۔

کیٹی: اور اب کسی متنازعہ سوال کے لئے ، خواتین کو کیٹو ڈائیٹ بالکل نہیں کرنی چاہئے یا نہیں اس بارے میں بہت سی رائےیں ہیں اور اگر ہم اپنے ہارمونز کی بنیاد پر کچھ خاص طریقوں سے اس میں ترمیم کرسکتے ہیں۔ I know personally I feel like I can do it fine especially if I cycle it and I test a lot of different markers and I handle it well, but I also handle fasting really well and some women don’t. There’s a very personalized aspect to this. So based on your research and experience, do you think that the keto diet is also effective and/or safe for women?

Dr. Dominic: Yeah, I can’t make that recommendation. I’ll give you my opinion. But so you may have trained your metabolism to be…and I think what I’ve observed is that there are women who simply initially they cannot fast at all. They get lightheaded and I mean, we’ve had individuals like almost faint in the lab, if not, you know, faint and just like can’t stand up after fasting. Women, their physiology is very responsive to changes and they could have orthostatic hypotension. They could have, you know, changes in just their brain energy levels. The female physiology, in my opinion, is that it’s much more reactive to low levels of glucose and insulin. So if your glucose gets low, that may have sort of a greater exaggerated response in a female compared to a male.

Males maybe tolerate fasting a little bit better. I don’t know if it’s a male thing to just kind of power through it but I definitely feel that there are physiological differences between females and males that make it harder for females to become robustly fat adapted. And one way to train your metabolism to be more fat adapted or keto adapted is to do things like intermittent fasting and then transition more gradually to eating low carbs and over time I feel like you could train your metabolism. But many women just tend to feel better adding some form of carbohydrates to the diet and I would say I’m of the opinion that a lower-carb diet would just be much healthier long term than a high carb diet and women who just cannot do the ketogenic diet for any reason I would advocate for them to at least do a lower carb diet or lower glycemic index diet and then capping carbs at like, you know, a one gram per pound, you know, or less if they really want to get metabolic benefits.

But I think people…I’m a big believer in self-experimentation. So I think people need to try the diet and see if it’s for them, and to honestly try a ketogenic diet, you have to stick with it for really six to eight weeks. A lot of people don’t want to hear that but you really have to honestly stick with it for six to eight weeks and measure your ketones to validate that you’re actually in a state of nutritional ketosis because once that blood ketone level gets elevated, that’s giving your brain an alternative form of energy and that’s where you really start to…the lights kind of come off and you start to feel a lot of the benefits of the ketogenic diet.

And for me, I went through, sort of, a learning curve to this and it probably wasn’t until the third month where I was like really myself totally, because I started with the Johns Hopkins protocol of like more of a dairy-based ketogenic diet and then I started transitioning off of that and was just doing more like whole foods and less dairy and I just had to find not only the macronutrient ratios but the types of foods that were working best for me. And also, it was kinda hard to get the calories. My metabolism was pretty fast, so it was kinda hard for me to get all the calories that I needed and that initial calorie deficit caused me to lose weight over time, especially the first…I think I lost about 10 pounds the first…without trying. I was actually trying not to lose weight. It was almost impossible not to lose weight.

So that side effect may be a benefit to a lot of people. They like the idea that they can eat and feel fully satiated and still continue to lose weight. And I don’t know of any other diet that can really allow you to do that unless you’re doing like a raw vegan diet, and that’s really hard to do, but a ketogenic diet I think has greater weight loss benefits than a raw vegan diet and it’s actually more practical from my perspective.

Katie: That brings up another point that I’m just personally interested in right now. Well, obviously the keto diet assists in weight loss and I have lost a significant amount of weight in the last year, not from only low carb, I’ve used a variety of methods and eat more food that I previous had. From your own experience, do you have any research or tips on how to gain muscle while still either losing fat or maintain fat loss? This is a balance a lot of people have trouble finding the sweet spot for.

Dr. Dominic: Yeah. So you are hitting on all great questions. So that’s a topic of debate, especially on social media in the fitness forums. Like, can you gain muscle on a ketogenic diet? There’s absolutely…I mean, we published a paper with our Italian colleagues back in 2012, I believe, and it was elite-level gymnasts that used a ketogenic diet and they were able to maintain their strength and they had more remarkable body composition alterations over time. So basically, you know, at the end of the study, they preserved their muscle and they lost more body fat. They did not gain any more muscle than the gymnasts that were following their standard dietary protocol, but so they had a very intense training routine and the amount of muscle that they gained was the same, actually they just maintained. So being able to maintain your muscle while you’re losing body weight and losing fat, like that’s actually a gain because, you know, if you lose weight but still have the same amount of lean body mass, that’s actually pretty significant.

So we established that early on and what we’ve learned over the years is that protein is actually really important. So the standard ketogenic diet requires, you know, a level of protein that’s restricted and in athletes, that’s probably not the best thing to do. So the data, as I understand it right now, from all the data that’s available, suggests that, you know, from a clinical ketogenic diet perspective, they tell you to have one gram per kilogram of body weight and you don’t need more than that. But for an athlete, you definitely need more than that, not only to maintain weight but if your goal is to gain muscle and strength, I would say 1.5 grams per kilogram at least, especially if you have a fast metabolism.

So I’m kind of heavy. I’m 100 kilograms, so for me, that’s 150 grams protein per day. And if someone, a clinical practitioner of the ketogenic diet, was to look at my diet and see me getting 150 grams of protein a day, well they would say, no, you’re nowhere near a ketogenic diet. But I am doing a ketogenic diet because my ketones would be elevated. So I think if someone’s a bit heavier and has more muscle and body mass, they can get away with more protein and they’re actually gonna need more protein to be able to retain that muscle and their need to increase protein higher than what would be a normal ketogenic diet to gain muscle over time.

So proteins are very, very important, obviously, for gaining muscle and the amount of protein you need. If your goal is strength and performance, if you’re an athlete, the amount of protein you need would probably be into that 30% of your diet range as opposed to a clinical ketogenic diet, which is like 10% to 15%. Like you literally need about double the amount of protein. And this gets into, you know, what is a hot topic now even in clinical medicine is the modified ketogenic diet. And that was actually advanced by Dr. Eric Kossoff at Johns Hopkins and the modified ketogenic diet, also called the modified Atkins diet, but the modified ketogenic diet is actually used for adults with epilepsy. And that’s like double the amount of protein than the diet that’s used for kids. And like I said, it’s much higher in protein, about 20% to 30% protein, relative to the pediatric epilepsy diet, which is like 12% to 15% protein.

Katie: Okay. That’s good. And I think that raises another question is what about fasting? I mentioned this earlier in the episode, and again, of course, with the caveat that some women will not handle this well. I feel like I do. I’m actually on day three of a water fast right now and my ketones are about 3.5 and I also pole vaulted this morning. But I’m curious, I know that you intermittent fast and you’ve also done longer fasts from what I’ve read. So what is your take on fasting for overall health and also for things like cancer prevention and all the other applications?

Dr. Dominic: Yeah. I’m a fan of fasting for many years. When I was really into weightlifting and strength training, I was eating like six meals a day and I would get anxiety if I went more than like three or four hours without a meal. So thinking that my body needs energy for growth and repair and that I would be taking a step backwards if I didn’t have that meal. But over the years, I’ve learned that once your body is adapted to burning fat and ketones for fuel that the ketones are very protein sparing and that has resulted in the whole area of science that we’re really focused on now with cancer cachexia, so muscle-sparing effects of ketones.

So my Ph.D. student that just graduated did a whole Ph.D. dissertation studying the anti-catabolic effects of ketones. So what that means is that, you know, if you are following a low-carb diet or doing a ketogenic diet and you do periodically fast, whether you do intermittent fasting or short-term fast or even long-term fast like a week or more, your body is more metabolically tuned to spare that muscle protein. And I think there’s clinical evidence to support this. And also, well, we have some work to be published, once you fast and once you do it a few times, you can actually enter the state of ketosis faster. So if you do fasting or you did the ketogenic diet and get off of the ketogenic diet, do like a standard diet and go back to fasting or go back to a ketogenic diet again, your body will make ketones much faster.

It’s almost like you know when you work out, you have muscle memory and you work up to like a certain level of bench press, you take time off…it may take you two or three years to get up to 200-pound bench press, but if you take a couple of months off, you’re going to lose a lot of that strength but if you start back up again, instead of two years, you can get back up to that level in like two months. Your metabolism is the same way. If you train your metabolism to burn fat and make ketones and burn ketones and you do it over time, the more you do it, the easier it gets and the more benefits you derive from it but also the faster your body jumps back into that fat-burning mode when you start fasting again or when you do a ketogenic diet. So that has pretty important practical implications.

I’m a fan of fasting. In the beginning, I was not. I had to be sold on it. And it was actually the scientific literature, reading paper after paper of the benefits of periodic calorie restriction, intermittent fasting, and ketones, which got me thinking as an academic scientist, you know, I’m doing this in the lab and I’m seeing the benefits. We solve very real benefits in the lab, even survival from things like metastatic cancer that I had to do this myself and I had to experience it myself and I’m kind of a self-experimenter. So over the years, I’ve done up to a seven-day fast, you know, and periodically, I like to do it when I’m traveling, and my wife and I travel together most of the time, but if I’m traveling alone and I know she’s not with me and having to eat because she doesn’t really do a lot of the crazy things I do. If I’m traveling alone, I like to just fast occasionally and traveling, that can be kind of convenient.

So I personally do it, I’ve experienced benefits from it that I’ve documented, and I’ve been in touch with many other people who do this. And I think it really does have real benefits. I think some people take it a little too far, but if you were to do a short-term fast for a couple of days, you know, every few months, I think that’ll really translate to real-world benefits.

Katie: As we get close to the end, I’d actually love to do a round two with you one day, I know that you’re very much in the research and a lot of people listening are women, but I’d love if we could talk about some practical takeaways that we can all learn from your research. So moms, parents, those of us who may not be lifting heavy weights, what are some of the things you’re seeing in the data right now that we can all learn from and adopt and benefit from doing?

Dr. Dominic: Yeah. Well, for women specifically, I think it’s really important for women when they start a ketogenic diet or they do intermittent fasting, a lot of times this scenario presents that women will start a new exercise routine so they’ll bump up their exercise, they will calorie restrict, and they’ll start the ketogenic diet all at one time. And so you have a lot of variables contributing to things that could potentially slow down your metabolism and decrease YOUR thyroid level. So if you are experimenting with a ketogenic diet, I would say keep all variables sort of the same and do not restrict your calories. So just adjust the macronutrient ratios to ratios that would be ketogenic and keep your training the same and see how it affects your body and let your body adapt to that because there’s gonna be some initial stress, you know, associated with the adaptation. And once your body adapts to that, then start, you know, adjusting the calories or ramping up your training and things like that.

So I think that’s really an important practical takeaway because it seems like so many women who start a ketogenic diet or start intermittent fasting also start, you know, they do it for contest preparation or they do it for a sport or to just to lose weight for a particular event. They like shotgun a lot of things at once. So they do ketogenic intermittent fasting, calorie restriction, and overexercising, and simply just overexercising can, sort of, drop your metabolism if you’re over-trained. So I think it’s important to kind of ease into this, more important for women than for men. So kind of say that off the bat. And also the exogenous ketones that are on the market right now really can help people transition into that, help people get through that initial keto flu, as some people call it, or that transition from a carbohydrate-based metabolism to a ketone-based metabolism.

So for intermittent fasting, for example, they may want to break the fast not with a big protein meal, but maybe with a ketone supplement and they can extend the benefits of the fast I believe because your glucose level would still stay low and your ketones would be elevated. And then maybe, you know, two or three hours later, have a balanced meal or a ketogenic meal, you know, for example, they may want to do that. And that has made transitioning into these things a little bit easier for them. And there’s so many resources that are available too online whether it be recipe books, even snacks.

So I do have the opportunity to test a lot of foods that are emerging on the market. Some of them are not on the market yet, but I can tell you there are a lot of, you know, ketogenic chocolates that are coming out, ketogenic brownies, ketogenic cookies, and some of them are ketogenic and some of them are not. But the good thing is that there are legitimate forms of chocolate bars and brownies and cookies and things that are entering the market. I’m a big fan of just whole food nutrition, but some of these snacks are really…these comfort foods are important to have time to time because otherwise a lot of people may feel deprived. And I know it certainly helps for kids because some kids that follow the diet kind of feel ostracized if they’re not able to eat certain foods. So that has made the transition for kids who need to follow it for a medical reason, it has made it much easier for them.

So there’s a lot of practical things that we’ve sort of garnered over the years, knowledge that we’ve learned, and also companies are developing technologies that are making the diet easier to implement and also easier to monitor. For example, Readout Health has a device that’s a breath acetone meter that I used all day today to check my own ketone levels. So BioSense is the device and instead of having to prick your finger and draw blood, you just simply blow into this device and it tells you your breath ketone levels. And I could blow into it hundreds of times and not have go buy strips. You just buy the device and it’s super easy to use. You can download the app and it tells you, it tracks all your ketone levels, and breath acetone is a very good marker of fat oxidation. So the higher that breath ketone level, you know you’re really cranking out, you’re really burning lots of fat if that level gets higher.

So for people, you know, the everyday person, and I know many people are looking at, you know, this approach to burn fat, something like the breath acetone meter by BioSense, you know, without having to stick your finger and pay for all the strips would be a very useful practical device for people.

Katie: Got it. I’m curious, what are you excited for in the future of research? Are there trends that you’re seeing right now that you think are up and coming that we should be excited about in this area of research?

Dr. Dominc: Yeah, there’s a lot of activity in this area and it’s kind of surreal to see because when I started studying this, it was pediatric epilepsy was the only application and it was very marginalized even at the American Epilepsy Conference, but now there’s just so much buzz all over. And the things that I think are gonna be most important in the future are like big health issues. Obesity we know is kind of a big problem but Type 2 diabetes is like a huge problem, especially in the over-50 crowd and it’s a huge healthcare burden. So Virta Health is doing a lot of work and the Virta Health website really documents all the studies that they’ve published.

And you know, a lot of people when they hear that a ketogenic diet can treat Type 2 diabetes, of course, they become skeptical that you can get patients off insulin or their medication but they do and, you know, they’ve proven this. And that’s been really interesting to see that science evolve. And we’re in a completely opposite direction. We’re working with the military and our company, Ketone Technologies, we sponsor research, working with NASA on various projects. And at this point now, it’s really understanding extreme environments and ultimately, you know, trying to formulate metabolic-based strategies including nutritional strategies that can optimize performance and safety of the warfighter, but also the astronaut.

So my wife and I had the opportunity to participate in the NASA extreme environment mission operations where we’re on a crew with astronauts and we’re under the Atlantic and we actually do research for a week or more underneath the water. We were living in a hyperbaric environment and I had the opportunity to do the ketogenic diet for 10 days submerged underwater. And if it was…you know, we’re still analyzing the data from that a couple of years later and we’re preparing for more space analog missions, you know, with NASA this year.

So that’s a big part of what we’re doing now and a lot of time, effort, and money and resources are being kind of channeled into understanding these extreme environments and developing what we think could be a ketogenic strategy for optimizing performance in these environments.

Katie: Definitely. I follow your research really closely and I think it’s amazing just to see everything that is coming up right now, and I’ll definitely keep watching in the future. Like I said, I’d love to do a round two one day if you’re willing, but I’m really grateful for your time today and sharing your expertise.

Dr. Dominic: Absolutely, I will. Thanks for having me on, Katie. Appreciate it.

Katie: And as always, all of you for listening and sharing one of your most valuable assets, your time, with us today. We’re so grateful that you did and I hope that you will join me again for the next episode of the “Wellness Mama” podcast.

If you’re enjoying these interviews, would you please take two minutes to leave a rating or review on iTunes for me? Doing this helps more people to find the podcast, which means even more moms and families could benefit from the information. I really appreciate your time, and thanks as always for listening.

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