How to SelfDecode Your Genetics


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Katie: Hello and welcome to the “Valence Mama Podcast”. I’m from KatieWellensmama.com and Wellensy.com. It has a valence with an “E” at the end. This is a new line of our personal care products including hair care and toothpaste designed to nourish your body from the outside out without any junk.

In this podcast episode, we take an in-depth look at genes and practical ways you can improve your health based on knowing and understanding your genes. I’m here with Self-D-Code Joe Cohen, and he’s self-explanatory that he’s won the genetic lottery for bad genes. As a child, he suffered from all sorts of inflammation, brain fog, fatigue, digestive problems, anxiety, depression and many other issues that were considered bad by his doctors. Frustrated with the lack of good information and tools, he decided to embark on a journey of self-experience and self-learning to improve his health, as many of us now call bio-hacking. Is famous And after creating a bio-hacker’s ultimate resource website called Self-Hacked, he founded Self-Decode, the ultimate biotech software platform for DNA-based health research, and we’re explaining that today. Explain how you can use your personal genetics to understand health recommendations and how to accomplish your goals through a mix of the different types of science that are now available.

Very interesting event, I think we will finally have to do two rounds because there is so much to add to this topic. But for now, welcome to that podcast. Joe, welcome. Thanks for coming here

Joe: Katie, thank you for keeping me.

Katie: I’m really excited to jump in a ton and learn from you about my genes, but the point is that we can use this knowledge to improve our daily lives or to improve our health. How to improve the results, especially as we age and I think it’s so interesting because, at least from the research I’m looking at, we’re only 10 years old now. Knowing more than that, it feels like it’s a never ending research topic. And that’s very interesting to me. I know it’s still in the minds of a lot of people, with a lot of news about various genetic factors related to immune health and respiratory infections. And I think we have the ability to look at that statistic in a unique way. So to get started there, I’d like a kind of start-up. I have a question for you about the resemblance of a palace and I like that if you can explain it you will start from there.

Joe: Yeah, of course then, basically, you have to think about the immune system as a castle, right? And it’s also about genetics, and how it works, like, because we basically classify an individual’s genetics into three different categories. So, if you have a fortress, for example, you know, the first way; you know, say that if you have an invading army, then the invading army is always trying to do what Yeah Al that sounds pretty crap to me, Looks like BT aint for me either. You know, castles are very strong and they try to find that weakness, some underground tunnel, some kind of piping system that you might know is easy to get into, it’s not very well fortified. ۔ And so, if we look at it as a respiratory infection; you know, we can use CoVID as an example, because it’s the most common in the news right now.

A very important gene that has been mentioned a lot is ACE2, right? And what it does is basically like an admissions system for coronaviruses. It’s a kind of thing, the enemy found a way to enter the palace. They, you know, have found this piping system that allows them to enter the fort. And so, this kind of you know, so it’s number one in search of registration. And that’s why it’s important to look for admissions; and, you know, there’s a difference in the population at how likely you are to get a respiratory infection. So let me give you an example. Let’s say it’s like a viral molecule in the air, and let’s just say, you know, you breathe in a viral molecule, you don’t necessarily bring an infection, right?

So the reason is that even after that he has to do other things, right? If there is only one soldier walking in the palace, he doesn’t have to just enter, right? They have to have this weakness or, you know, the genetic variant, the weakness that allows them to enter the palace. And so ACE2 is like a piping system that allows the invading army to enter, let’s say the Corona virus is allowed to enter the army. And that’s a lot in the news. So that’s one thing. Entry is a big title.

The second title is, we say the soldiers in front of you. So once the virus enters the body, you always have the first letter that you can still avoid; you can still minimize the damage. We say that some soldiers entered, they already found a way, but you know, your body was able to reduce the damage, and the attack was not so big. There were not many such symptoms. And so what we’re seeing is, let’s say in a quote, you know, a lot of researchers are saying up to 50% that we’re not. And, you know, every kind of infection, really, almost every one, there are a lot of people who are rude and it can be different. But the thing is, you know, we’re seeing a lot of rude people and because you can rely on your first line about the infection, whether it’s a baby or something. And then the next area that we’ve seen about genetics, and only in general, that’s what you want to think about, it’s like an emergency response.

So in a castle like yours, come on, you know, when the castle is violated and the bells are ringing, that’s all; you can do anything to get rid of this virus. The invading army must be expelled. . If you are killing your own people, well … you can do it right, well, to get the invading army out. So if you have to throw fireballs that kill your own citizens, that’s something you can do if they already exist; you know, it either goes down the castle. Is. And so, that’s actually the biggest component of what we’re looking at, because that’s why things really go wrong, right?

And so, for example, like inflammation. And IL-6 is a great example of that. But there are really many, many inflammatory molecules that can cause you genetic problems that can eventually get on the plane, right? So in the palace, it could be, you know, a kind of last line of defense, where, you know, everyone is doing their own thing and a suicide attack is being carried out. In the body, it’s like IL-6. So there’s something in Antilockon 6; you know, you want it to be balanced. If it is at a low level, it may help fight infection. But if it gets too high, then it can kill and damage your own cells. And the problem is that when things just get chaotic, the effect increases, and then the body can do a lot of damage, a lot of inflammation, and that’s why it’s hard to breathe.

So the same complications from covid actually occur in other respiratory viruses. It’s called ARDS, which is a severe respiratory distress syndrome, it’s a cytokine storm and it’s basically exactly what it looks like. There are a lot of inflammatory cytokines here, it’s a storm and it’s an overshot. There is so much more. It causes the lungs to collapse, causing the body to go insane. And that’s where the complications come from. And, you know, researchers think that, if you already have an imbalance, you know, if you already have an imbalance, tell, for example, if you have COPD Or heart disease, so often these cytokines are already elevated. If you are not healthy then they are out of balance. And similarly, when you have a respiratory infection, it can basically ignite the fire and then make it a little more insane. And that’s the kind of place where, you know, the general health of the body comes into play, you know, the castle soldiers are in good health and comfortable, and they’re able to fight that infection.

Katie: I like that resemblance. And it also speaks to the fact that our genes are not our destiny. Because I think it’s something that makes it difficult when people start learning about their genes or find out they have certain genes, whether it’s methylation issues or COMPT or whatever, they feel it is their destiny or they don’t. It doesn’t look like they can do much about it. And the thing I love about you guys is that you give people their genes and you explain them, but you also follow practical ways so that they can use these genes in every possible way. Can help So let’s talk about that, in a broader sense, and then we can go deeper into certain types. But can you talk about the power we have? You know, you mentioned it a little bit in them, but how can we support our body in different ways, even if we have more and more genes in different categories?

Joe: Yeah Al that sounds pretty crap to me, Looks like Al that sounds pretty crap to me, Looks like Al that sounds crap to me, Looks like Al that sounds crap to me, Looks like Al that sounds crap to me, Looks like Al that sounds crap to me, Looks like Al that sounds crap to me. So if we take something like diabetes or heart disease, we know they are diseases; they are highly treatable, right? If you’re exercising, if you’re doing a lot of healthy things, diet, everything, well, you know, your blood sugar will be more balanced, your heart health, your blood vessels, your Know, your bleeding, everything will be more balanced. We know that there are problems like this and many more, but for just one example they say that these things, they depend more on your environment and how healthy you are. And we also know that they have a strong genetic component, right?

And so what does that mean; and I have a lot of family, we say he died of a heart attack. This is not a coincidence, you know, many members of the same family from my grandmother, they all had heart disease, and they died of the same cause, but they lived longer. Stay, okay? So my grandmother, for example, was always healthy. She was 93 years old, while her sisters were only 40 years old, most of them. Okay fine? And so what we’re seeing is, you know, we have this genetic component and that’s important, but you’re able to fight it even when you’re healthy. And what we’re trying to do is, you know, basically tell you something else about staying healthy, well, basically how to stay healthy for you.

So we’re starting with, “Here are some really good recommendations for improving your thyroid health, whatever your mood problems, to improve your heart health.” Here are the top recommendations, and then let’s prioritize them a bit based on our genetics, because we also know that the same things don’t work for everyone, right? Everyone knows you did. Some have tried that someone else has worked for them and it doesn’t work for you, so what we see is that these are the things that can help and we see that too. That doesn’t necessarily help everyone, and that’s where genetics comes in. What’s the difference in your response to genetics?

But when it comes to diseases like اور and you know, if you are really much healthier, you can really avoid all these kinds of chronic diseases. And what we’re trying to do is give you, like; basically a little bit of priority. You know, we’re starting with things that will help you in a particular topic. That’s why we always suggest, first choose a topic that interests you, right? So if it’s thyroid, if it’s mood, you pick the subject and say someone already has some kind of mood. They may be upset or depressed, then obviously there are some genetic factors because the whole population is not like that and a lot of people are unhealthy or eating anything.

So you start with this topic, and then we’re giving you recommendations that are generally good for this topic and then prioritize them based on your genetics. And so, when it comes to things like methylation, it’s a bad way to do it because you’re not doing it on that basis; you’re not picking a title at first, right? You’re not saying, “Well, I have a thyroid problem. That’s the best thing I can do for the thyroid,” and then we prioritize them, right? Instead you are saying, “I have this gene and based on this gene, it is telling me that I have thyroid problems and after that, it is causing all my troubles.” Which I have never kept in my life. ” Okay fine? And that’s not usually the case. It can contribute to a single problem. But the thing is, the way to go about it with just one gene like methylation شن and then deduce a whole bunch of things from it, I think that’s the wrong approach. And the bottom line is, like you said, we don’t give information unless you can do something about it, right? What we have found is that all these genes, always some lifestyle, some kind of supplement, some will prove to be healthy for the subject, which can also eliminate the negative effects of this gene. ۔

Katie: Gota, it makes sense. And it makes sense to combine them with the symptoms and the actual results; I think you’re fine. Methylation was a big topic when people started to understand it, and there were a lot of articles that came out about the different forms of MTHFR and what it meant. So to go a little deeper into it? , Are there any recommendations we can implement based entirely on genetics or do you think you should weigh the symptoms too? So, in other words, does everyone need to take MTHFR changes, for example, taking methylflot or is it more important than that?

Joe: So generally, I don’t think so, right? There are some exceptions, but as a general rule, if you have a certain mutation for a gene, that doesn’t mean you should do something, right? If you have a different MTHFR, let us know, and you’re eating a natural diet and your folate levels are high, well, you’re not taking artificial folate, you know, کچھ نہیں کررہے ہیں ، ٹھیک ہے ، آپ صرف مصنوعی فولیٹ نہ لیں ، آپ کا ہومو سسٹین کم ہے ، لہذا آپ اپنے لیبز کی جانچ کررہے ہیں ، اور اگر آپ کے پاس کوئی علامت نہیں ہے تو اس کے ساتھ کوئی تعلق نہیں ہے ، ٹھیک ہے۔ آپ جانتے ہو ، ایم ٹی ایچ ایف آر کا تعلق پریشانی اور افسردگی سے ہوسکتا ہے ، اس کا تعلق دل کی بیماری سے ہوسکتا ہے۔

لیکن ان علامات میں سے اکثر کو عمل کرنا پڑتا ہے… مثال کے طور پر ، ہومو سسٹین ، عام طور پر ، اس کے اثرات کے ل generally عام طور پر یہ زیادہ ہونا پڑے گا… آپ جانتے ہو ، ہومو سسٹین یہ دیکھنے کے ل good ایک اچھا طریقہ ہے کہ آپ کی میتھلیشن کیسی ہے۔ تو ایم ٹی ایچ ایف آر کچھ اچھی بات ہوگی جو پھر آپ کو بتائے گی ، “یہ وہ لیبز ہیں جن کی آپ کو جانچ پڑتال کرنے کی ضرورت ہے۔” اور یہی دراصل ہے… اس کی وجہ کہ ہم لیبز کو خود ساختہ طور پر ضم کررہے ہیں کیوں کہ ہم یہ نہیں سوچتے کہ ، آپ جانتے ہیں ، آپ اپنے جینوں کو دیکھتے ہیں اور پھر آپ نتیجہ اخذ کرتے ہیں۔ نہیں ، آپ کو یہ یقینی بنانا ہوگا کہ اگر آپ لیب کو چیک کرسکتے ہیں ، تو آپ کو ایم ٹی ایچ ایف آر کے ساتھ ہونا چاہئے ، اس کے لئے یہ ایک عمدہ مثال ہے۔ آپ یہ یقینی بنانا چاہتے ہیں کہ آپ اسے کسی علامت سے بھی جوڑ رہے ہیں جو آپ یا کسی اور چیز کو پریشان کررہا ہے… ٹھیک ہے۔ اگر یہ موڈ کی پریشانی ہے تو ، ہاں ، اور آپ کے پاس ایم ٹی ایچ ایف آر کی منفی قسم ہے اور آپ کا ہومو سسٹین زیادہ ہے ، اس صورت میں ، آپ اس کے بارے میں کچھ کرنا چاہتے ہیں۔ ٹھیک ہے؟ لیکن جین کے بارے میں کچھ کرنا چاہتے ہیں اس کی وجہ منفی تغیر کافی نہیں ہے۔

کیٹی: گوٹا ٹھیک ہے. اس کو وسیع رکھنے کے ل some ، اور کچھ ایسی مثالیں کیا ہوں گی اور پھر ہم ان اقسام کی قسمیں ڈائل کریں گے ، جن کے بارے میں آپ کو لگتا ہے کہ عام طور پر لوگوں میں مختلف جینیاتی تغیرات موجود ہوں گے۔ اور پھر اس کی وجہ سے ، ایسی سفارشات ہیں جو ان کے لئے زمرے میں ، ایک بڑا فرق بنا سکتی ہیں۔ میں سیلف ڈیکوڈ میں جانتا ہوں ، میں ابھی نظر آرہا ہوں ، جس کا تعلق لمبی عمر سے ہے ، میٹابولک صحت ، سوزش سے ہے۔ کیا ایسی کٹیگریز ہیں جن سے ایسا لگتا ہے کہ وہاں ایک مضبوط ارتباط ہے؟

جو: ہاں تو ہم کہتے ہیں کہ اگر ہم مزاج لیتے ہیں ، مثال کے طور پر ، موڈ کا مسئلہ متعدد مختلف امور کی وجہ سے ہوسکتا ہے۔ اور جیسا کہ ہم دیکھتے ہیں ، آئیے بتائیں ، آپ کو معلوم ہے ، ایس ایس آر آئی مددگار ثابت ہونے کے بارے میں ایک بڑا تنازعہ ہے اور ، آپ جانتے ہیں ، میری سمجھ اور اس کے مطابق جو میں نے پڑھا ہے ، وہ آبادی کے ایک خاص فیصد کی مدد کرسکتے ہیں لیکن وہ ضروری نہیں ہے زیادہ تر لوگوں کی مدد کریں جو اسے پلیسبو اثر سے باہر لے جاتے ہیں۔ ٹھیک ہے؟ اور یہ ایک مثال ہے جہاں جینیات کے کھیل میں آسکتے ہیں ، ٹھیک ہے؟ خاص طور پر ایس ایس آر آئی نہیں ، لیکن صرف یہ جاننا کہ کیا کم سیرٹونن موڈ کی پریشانیوں کا سبب ہے۔ ٹھیک ہے؟

اور اسی طرح ، میرے لئے ، مثال کے طور پر ، میں جانتا ہوں کہ میرے پاس سیروٹونن سے متعلق بہت سارے جین ہیں جو سیرٹونن کے ذریعہ بہتری لائیں گے ، ٹھیک ہے؟ اور اس طرح کچھ… میرے لئے ، مثال کے طور پر ، ایک بار جب مجھے پتہ چلا کہ ، میں نے 5-HTP لینا شروع کیا اور اس نے میری مدد کرنا شروع کی ، ٹھیک ہے؟ مجھے اس سے اچھا اثر پڑا اور میں نے اسے دوسرے معاملات میں بھی دیکھا ہے۔ جب میں کسی سے ڈیٹنگ کر رہا تھا ، اس کے موڈ میں بہت سخت مسائل تھے ، اور ہم نے اس کی جینیاتیات کو دیکھا ، اور اس کے پاس واقعی سیرٹونن جین تھے ، ان میں سے کچھ بہت ہی ، اور وہ رات کو 5-HTP اور ایک دوسرے ضمیمہ سے بدل گئی ، آپ جانتے ہو ، لتیم orotate. ٹھیک ہے؟ وہ حقیقت میں کبھی بھی ان سے دور نہیں جانا چاہتی تھی کیونکہ وہ کبھی بھی اس کی جانچ نہیں کرنا چاہتی تھی اور دیکھنا چاہتی تھی کہ کون سا یا دونوں… وہ سوچتی ہے کہ یہ دونوں ہی ہیں ، لیکن بنیادی طور پر اس کی زندگی اسی رات سے بدل گئی۔

اور یہ وہ چیز ہے جسے میں خود ہی دیکھ سکتا تھا ، ٹھیک ہے؟ ان میں سے بہت سے لوگوں کے پاس جن کی کامیابی کی کہانیاں ہیں میں انھیں پہلے سے نہیں دیکھ سکتا ہوں۔ لیکن بات یہ ہے کہ اگر ہم مزاج کے بارے میں بات کر رہے ہیں تو ، یہ سیرٹونن سے متعلق ہوسکتا ہے۔ یہ کسی طرح کا بایوکیمیکل راستہ ہوسکتا ہے جس کا تعلق موڈ سے مختلف انداز میں ہے ، ٹھیک ہے؟ اور ایسا ہی کچھ ، آپ جانتے ہو ، اس کے ل other اور بھی بہت سی چیزیں اچھی ہوسکتی ہیں۔ یہ ڈوپامائن سے متعلق ہوسکتا ہے۔ یہ GABA سے متعلق ہوسکتا ہے ، ٹھیک ہے؟ آپ جانتے ہو ، اور پھر ، جیسے ، یہاں صرف ایک پورا گچھا ہے… یہ نیوروجنسی سے متعلق ہوسکتا ہے۔ تو کچھ دوائیں ہیں یا کچھ سپلیمنٹس ، یا… زیادہ تر سپلیمنٹس کسی نہ کسی طرح نیوروجنسی کو بڑھاتے ہیں۔ ورزش کرنا۔ اس قسم کے صحت مند سلوک بہت سے اعصابی اعضاء میں معاون ہیں۔

لہذا ، مثال کے طور پر ، میرے پاس کم BDNF ، کم BDNF ہے ، اور یہی دماغ سے حاصل شدہ نیوروٹرو فک عنصر ہے ، یہ بنیادی طور پر اس طرح ہے… یہ دماغ کے لئے پانی ہے اور اس سے نیورانوں کو بڑھنے میں مدد ملتی ہے۔ میرے پاس نچلے درجے ہیں اور میں جانتا ہوں کہ اگر مجھے کافی سورج نہیں ملتا ہے یا اگر مجھے نہیں آتا… آپ کو معلوم ہے ، یہ تو سورج ہے یا کافی ورزش ، میرا موڈ ڈرامائی طور پر نیچے جاتا ہے۔ اور ہوسکتا ہے کہ کچھ دوسرے لوگوں کو بھی اسی ڈراپ کا تجربہ نہ ہو۔ لیکن سورج واقعی اہم ہے ، بی ڈی این ایف میں اضافے کے لئے روشنی اور سورج واقعی اہم ہے۔ اور یہی وجہ ہے کہ میں ہمیشہ رہنا چاہتا ہوں ، جیسے دھوپ والے علاقے میں کیونکہ میرے لئے ، جیسے ، اس کا واقعی میرے موڈ پر بڑا اثر پڑتا ہے۔ اور اگرچہ اس کا اثر ہر ایک کے مزاج پر پڑتا ہے ، شاید اس وجہ سے زیادہ میری اس وجہ سے کہ مجھ میں BDNF جین میں یہ تغیرات پائے جاتے ہیں۔

کیٹی: سمجھ گیا یہ دلکش ہے۔ اور میری اپنی رپورٹ کو پڑھنے سے ، ایسا لگتا ہے کہ سورج کی نمائش اور وٹامن ڈی ، یہ ایسی ہی چیز ہے جو لگتا ہے کہ یہ کچھ مختلف امکانی جینوں کی مدد کرتا ہے۔ کیا یہ ایک مشترکہ تھیم ہے؟

جو: ہاں تو دلچسپ بات یہ ہے کہ ، جیسے ، آپ جانتے ہیں ، جس طرح سے آپ عام طور پر دیکھ رہے ہیں کہ کچھ صحت مند کیوں ہے ، کیا آپ کہتے ہیں ، “ٹھیک ہے ، سورج حاصل کرنا صحت مند ہے ، ٹھیک ہے ، کیونکہ یہ صحت مند ہے ، وٹامن ڈی ،” آپ جانتے ہیں؟ آپ واقعی میں اپنے جین کے معاملے میں اس کے بارے میں نہیں سوچتے۔ لیکن پھر جب آپ واقعی ، اس میں ڈوبتے ہیں ، ٹھیک ہے ، تو آپ اس کی بایو کیمسٹری دیکھتے ہیں ، آپ کہتے ہیں ، دلچسپ ، یہ اس مسئلے پر اس جین کے منفی اثر کا مقابلہ کرتا ہے ، ٹھیک ہے ، چاہے وہ بی ڈی این ایف اور مزاج ہی کیوں نہ ہو۔ لہذا یہ بی ڈی این ایف میں اضافہ کرتا ہے اور اس سے مزاج بہتر ہوسکتا ہے۔ ہم پہلے ہی جانتے ہیں کہ اس کے مزاج میں بہتری آتی ہے ، روشنی میں رہتے ہوئے… ٹھیک ہے؟ لیکن ہم مزید تفصیل دیکھتے ہیں کہ یہ کس طرح موڈ کو بہتر بنا سکتا ہے۔

اور اس طرح ہم دیکھتے ہیں ، نہ صرف آپ جانتے ہیں ، صرف عام مطالعات جیسے کہتے ہیں ، چلیں ، آپ کو معلوم ہو ، “آپ جتنا زیادہ باہر ہوں گے ، خوشی سے زیادہ آپ ہیں” ، جو بھی ہو۔ اگر آپ کسی سنہری جگہ پر رہتے ہیں تو ، آپ کو خوشی مل سکتی ہے یا جو کچھ بھی ہے۔ نقطہ یہ ہے کہ ہم مخصوص جیو کیمسٹری دیکھتے ہیں کہ ، اوہ ، سورج بی ڈی این ایف میں اضافہ کر رہا ہے ، اور بی ڈی این ایف ہمارے موڈ کے لئے واقعی اہم ہے اور ، آپ جانتے ہو ، حوصلہ افزا مزاج اور اس طرح کی چیزیں۔ لہذا ہم جو دیکھ رہے ہیں وہ یہ ہے کہ عام طور پر صحت مند طرز عمل سے وہ بہت سارے منفی جینیاتی تغیرات کا مقابلہ کرتے ہیں۔ اور اس سے یہ معنی ہوگا کہ اگر آپ زیادہ سے زیادہ زندگی گزار رہے ہیں تو ، ہمیں بہت سارے معاملات نظر میں نہیں آتے ، ٹھیک ہے؟

ہم ذیابیطس یا قلبی بیماری یا بہت سارے دوسرے معاملات نہیں دیکھتے ہیں۔ ابھی ، بعض اوقات لوگ زیادہ سے زیادہ زندگی گزارنے کی کوشش کر رہے ہیں اور وہ سب کچھ نہیں کرسکتے ہیں ، اور یہ بات قابل فہم ہے۔ لہذا ، آپ جانتے ہیں ، ہم جو کچھ کر رہے ہیں وہ ہے ہم آپ کو یہ بتانے کی کوشش کر رہے ہیں کہ ، “یہاں وہ چیز ہے جس پر آپ کو زیادہ توجہ دینی چاہئے۔” ٹھیک ہے؟ ورزش ہمیشہ صحت مند رہنے والی ہے ، کچھ اعتدال پسند ورزش۔ باہر جانا ہمیشہ صحت مند ہوتا ہے۔ آپ کو یہ کبھی نہیں کرنا چاہئے کیونکہ یہ آپ کے جینیات میں نہیں ہے۔ آپ جانتے ہو ، یہ کوئی سفارش نہیں ہے ، لیکن ہم دیکھتے ہیں ، جیسے آپ کہتے ہیں کہ یہ چیزیں صرف سفارشات میں بہت کچھ سامنے آرہی ہیں ، کیونکہ آپ جانتے ہیں ، یہ وہ طریقہ کار ہے جس کی مدد سے یہ عمل کرتی ہے۔ اور اس طرح بھی اگر آپ پہلے سے ہی موجود ہیں ، آپ جانتے ہو ، ہر روز ورزش کرتے ہیں ، مجھے لگتا ہے کہ یہ ضروری ہے… کم از کم ، یہ جاننا بہت دلچسپ ہے کہ ، “اوہ میرا بی ڈی این ایف کم ہے۔ میں سمجھتا ہوں کہ ورزش کیوں ہے ، آپ جانتے ہو ، مجھے بہتر موڈ میں بناتے ہو “یا” مجھے اپنے اوپیئڈ جین یا اپنے اینڈوکانا بینوائڈز سے مسئلہ ہے ، اور میں سمجھ سکتا ہوں کہ ورزش مجھے اپنے موڈ کو بہتر بنانے میں کیوں مدد کر رہی ہے۔ ” ٹھیک ہے؟ تو ، ہاں ، میں سوچتا ہوں… جیسے ، میں بالکل اس کے ساتھ اتفاق کرتا ہوں جو آپ کہہ رہے ہیں ،

کیٹی: کیا آپ کو ایسا لگتا ہے ، جیسے کی بنیاد پر… جیسے ، آپ ان چیزوں کو کس طرح ترجیح دیں گے؟ لہذا ، جیسا کہ ، اپنے جینوں کو دیکھنا ، میرے پاس لمبی عمر سے متعلق بہت کچھ ہے ، مثال کے طور پر ، اور پھر ان میں سے ان سب پر مبنی اضافی سفارشات ، اور طرز زندگی کی سفارشات ، اور غذا کی سفارشات ہیں۔ آپ کی سفارشات کیا ہیں یا ، جیسے آپ کس چیز کو ترجیح دیتے ہیں کہ کون سے آغاز کرنا ہے اور کون کون سے اہم ترین ہونے والا ہے؟

جو: تو ایک خاص عنوان کے ل number سب سے پہلے ایک سفارشات ہیں۔ ہم ہمیشہ ایک بہت اہم عنصر کے طور پر ، اس سے عنوانات کو کس طرح متاثر کرتے ہیں ، کو مدنظر رکھتے ہیں۔ لہذا اگر ہم لمبی عمر کی اطلاع کے بارے میں بات کر رہے ہیں تو ، ہم یہ یقینی بناتے ہیں کہ لمبی عمر کے لئے ہر سفارش اچھی ہے ، چاہے وہ آپ کے جینوں کو بہتر بنا رہی ہو یا نہیں ، ٹھیک ہے؟ اور اس طرح پہلا نمبر ہے ، جیسے… تو آپ پوچھ رہے ہیں ، آپ کس سفارش کو ترجیح دیتے ہیں؟ ہم آپ کے جینیات کی رپورٹ میں کرتے ہیں۔ ٹھیک ہے؟ لہذا ہمارے پاس اس طرح کی بلاگ پوسٹیں ہیں جو ایک وقت میں ایک جین پر مرکوز ہوتی ہیں اور آپ اسے ترتیب دے سکتے ہیں۔ لہذا آپ دیکھ سکتے ہیں ، مثال کے طور پر ، کہتے ہیں ، سانس کی بیماریوں کے لگنے کے ل I ، میں نے اوپر والے سات جینیاتی خطرے والے عوامل دیکھ سکتے ہیں جو شاید آپ میں پیچیدگیاں پیدا کر رہے ہوں یا کچھ ایسا ہی ہو۔ اور سب کے پاس کچھ ہے ، ٹھیک ہے؟ اگر اس عنوان پر ہمارے پاس 35 خطوط ہیں تو آپ کے پاس ان میں سے کچھ جینیاتی قسمیں ہوں گی۔ اور خیال یہ جاننا ہے کہ اس کا مقابلہ کیسے کریں ، ٹھیک ہے؟ لیکن ہمارے پاس یہ رپورٹ بھی ہے کہ بنیادی طور پر وہ کام آپ کے لئے کریں تاکہ ہم ہر پوسٹ کو لازمی طور پر پڑھنے کی کوشش کرنے کی بجائے اور ہر سفارش کو دیکھنے کی کوشش کر سکیں ، ہم کیا کرتے ہیں ہم اس رپورٹ میں آپ کی سفارشات کو ترجیح دیتے ہیں کہ تم سمجھے. اور اسی طرح پہلے نمبر پر کیا آپ رپورٹ میں ترجیحی سفارشات کو دیکھنا چاہتے ہیں ، 1 ، 2 ، 3 کیا ہے؟ یہ عام طور پر 20 تک جاسکتا ہے۔

اور دوسری بات یہ ہے کہ کیا آپ سفارشات کو اسکین کرنا چاہتے ہیں اور کہتے ہیں… آپ جانتے ہیں ، کہتے ہیں کہ آپ اپنی علامات اور آپ کے لیب ٹیسٹ دیکھ رہے ہیں یا آپ کسی ڈاکٹر یا کسی طرح کے صحت سے متعلق پیشہ ور افراد کے ساتھ مل کر کام کر رہے ہیں اور وہ کہتے ہیں ، تجویز کردہ کچھ اور آپ کہتے ہیں ، “اوہ ، تم جانتے ہو کیا؟ یہ میری رپورٹ پر بھی سامنے آرہا ہے۔ مجھے اس کی مزید جانچ پڑتال کرنے دو ، “یا اس طرح کی کوئی بات ، ٹھیک ہے؟ تو یہ بہت ساری بات ہے… آپ جانتے ہو ، یہاں تک کہ جب ہم پہلے سے ہی عمومی زمرے کو لے رہے ہیں جس کے ساتھ ہم کام کر رہے ہیں ، چاہے وہ سانس کی بیماری کا انفیکشن ہو ، لہذا سانس کی بیماریوں کے انفیکشن کی سفارشات کے اندر ہر چیز ، ان کے پاس کچھ قسم کی مطالعے ہیں جن سے یہ ظاہر ہوتا ہے کہ یہ سانس کے انفیکشن میں مدد کرسکتا ہے۔ اور ہم وہ معلومات فراہم کریں گے تاکہ آپ دیکھ سکیں۔

لہذا آپ یہ بھی یقینی بنانا چاہتے ہیں کہ یہ صرف ہے… آپ جانتے ہیں ، بس اس پر نظر ڈالیں اور ایسا ہی رہیں ، آپ جانتے ہو ، “میں یہ لینے کے بارے میں سوچ رہا ہوں اور ، آپ جانتے ہو ، میں سمجھتا ہوں کہ یہ میرے جسم کے لئے اچھا ہے۔” لہذا آپ کو ایک عمومی جائزہ لینے کی ضرورت ہے ، چاہے وہ آپ یا ڈاکٹر یا کوئی اور ہو ، کوئی اسے دیکھتا ہے… اور آپ خود کر سکتے ہیں اور ایسا ہی ہوسکتا ہے ، آپ جانتے ہو ، “میں کچھ عرصے سے اشوگنڈھا لینے کی خواہش کر رہا ہوں اور میں ابھی یہ نہیں لے رہا ہوں “یا ، آپ جانتے ہو ،” مجھے اتنی حوصلہ افزائی نہیں ہوئی کہ میں ابھی کافی ورزش کروں۔ ” اور اس لئے شاید یہ آپ کو تھوڑا سا اضافی محرک فراہم کرے۔

کیٹی: گوٹا ہاں ، یہ دلچسپ ہے۔ میں اپنے ڈیٹا میں غوطہ کھا رہا ہوں اور تمام سفارشات کو دیکھ رہا ہوں۔ اور یہ سب دیکھنا واقعی دلچسپ ہے کہ ہمارے پاس ابھی معلومات موجود ہیں۔ یہ دلکش ہے۔ ایک منٹ کے لئے سانس کی طرف اور قوتِ مدافعت کی طرف واپس جاکر ، آپ کیا سوچ رہے ہیں ، جیسے… ظاہر ہے ، مدافعتی صحت ابھی ایک بہت بڑا موضوع ہے اور شاید یہ کچھ دیر اسی طرح برقرار رہے گا۔ کیا وہاں سفارشات میں کوئی مشترکات ہیں یا خاص طور پر پریشان کن جین جن کے بارے میں لوگ جاننا چاہتے ہیں؟ اور پھر آپ کے خیال میں ہم کس حد تک خطرناک عوامل ہیں ان میں سے کچھ زیادہ سے زیادہ سختی کو کم کرنے میں کامیاب ہیں؟

جو: لہذا ، جیسا کہ ہم نے بہت سارے دوسرے مسائل جیسے سانس کے انفیکشن دیکھے ہیں ، چاہے وہ ذیابیطس ہو یا قلبی مرض ، آپ جانتے ہو ، COVID یا سانس کے دوسرے انفیکشن کے ساتھ ، ہم کہتے ہیں کہ فلو ، ٹھیک ہے ، جو فلو سے مر رہا ہے ؟ وہ لوگ جو واقعی بوڑھے ہیں یا لوگ واقعی ، واقعی غیر صحت مند۔ ٹھیک ہے؟ اور اس طرح ہم کوویڈ کے ساتھ ایک ہی چیز دیکھ رہے ہیں ، جو بنیادی طور پر ، جیسے آپ جانتے ہو ، عام طور پر کون ہے…؟ عام طور پر ، یہ وہ لوگ ہیں جو غیر صحت مند ہیں یا بہت بوڑھے ہیں۔ اور اس طرح یہ ایک ہی طرز میں موزوں ہے۔ اور لہذا اس کا مطلب واضح طور پر یہ ہے کہ ، آپ جانتے ہو کہ ، آپ کو کتنا صحت مند ہونا پڑتا ہے اس کے ساتھ آپ کا جسم کتنا اچھا ردعمل ظاہر کرتا ہے ، نہ صرف کوویڈ یا کورونا وائرس بلکہ کسی بھی طرح کا انفیکشن۔ اور تو یہ واضح ہے ، ٹھیک ہے؟

اور اس طرح ہم کیا کر رہے ہیں ، آپ جانتے ہو ، ہم آپ کو ایسی چیزیں دے رہے ہیں جو کسی نہ کسی طرح مدد کریں گی ، ٹھیک ہے ، شاید علامات کو تھوڑا سا کم کریں ، شاید… آپ جانتے ہو ، اس کو کسی طرح سے مدد ملنی چاہئے ، سوزش کو کم کرنا تاکہ آپ… ہوسکتا ہے کہ یہ آپ کے مدافعتی نظام کے پاگل ہونے کا امکان کم کردے۔ تو ہم کیا کررہے ہیں کیا ہم سفارشات دے رہے ہیں کہ شاید ہم صحت مند رہنے کے لئے بہرحال دیں گے ، ٹھیک ہے؟ شاید وٹامن سی ، خاص طور پر ، ہم بتائیں کہ کیا آپ میں کسی چیز کی کمی ہے ، ٹھیک ہے؟ اگر آپ کو زنک یا وٹامن سی یا وٹامن ڈی کی کمی ہوسکتی ہے ، تو یہ دماغی نہیں ، ٹھیک ہے؟ مدافعتی نظام کے ل really یہ واقعی اہم ہیں اور آپ ان کو بہرحال لینا چاہتے ہیں۔ لہذا ہم ایسی چیزیں دے رہے ہیں جو عام طور پر بہت اچھی اور صحت مند ہوتی ہیں۔ زنک ایک اچھی مثال ہوسکتی ہے۔ اور پھر ہم اسے ترجیح دے رہے ہیں۔

اور اس طرح ، میں سوچتا ہوں کہ جو ہم دیکھ رہے ہیں وہ ہے ، جیسے ان جینوں کے لئے ، ہم وہی چیزیں دیکھ رہے ہیں جو ہمیں دوسرے طریقوں سے بھی نظر آرہی ہیں۔ صحت مند طرز زندگی کے بہت سے عوامل ہیں جو ان جینوں کی منفی تغیرات کا مقابلہ کرسکتے ہیں۔ اور اسی طرح ، مثال کے طور پر ، آئیے-آئی ایل -6 کی بات کرنے پر ، آپ کو معلوم ہو کہ ، یہاں جینیاتی تغیرات پائے جاتے ہیں جو بیس لائن IL-6 میں اضافہ کرسکتے ہیں یا اس میں اضافہ کرسکتے ہیں کہ یہ کسی انفیکشن کا کیا جواب دیتا ہے ، اور دیگر سائٹوکائنز بھی۔ میرے پاس کوئی IL-6 مسئلہ نہیں ہے ، لیکن میرے پاس IL-17 مسئلہ ہے اور آپ کے پاس حقیقت میں ایک جینیاتی تغیر ہے ، اور یہ حقیقت میں دوسری طرح کی سوزش کا سبب بن سکتا ہے جس کا میں نے ماضی میں مقابلہ کیا ہے۔ یہ سوجن کی ایک پوری میزبان… سوزش کی اقسام کا سبب بن سکتا ہے۔

اور اس طرح یہ کسی ایسی چیز کی مثال ہے جس سے میں سانس کے انفیکشن یا کسی بھی چیز سے قطع نظر ، ویسے بھی معاملات کرنا چاہتا ہوں۔ لیکن جب IL-6 یا IL-17 کی بات آتی ہے تو ، سائٹوکائنز کو کم کرنے کے بہت سے ، بہت سارے طریقے ، بہت سے ، بہت سے صحتمند طریقے موجود ہیں تاکہ وہ پاگل نہ ہوجائیں ، ٹھیک؟ اور جتنا پہلے آپ ان چیزوں پر پہنچیں گے ، بہتر ہے نا؟ اگر آپ انفیکشن سے پہلے اپنی صحت کو بہتر بنانے کے قابل ہیں تو ، یہ سب سے بہتر ہے۔ اور لہذا ہم ہمیشہ آپ کو علاج سے بچاؤ کی سفارش کرتے ہیں۔ ٹھیک ہے؟ And when it comes to treatment, there’s no, let’s say, clinical studies that will say vitamin C can help COVID. We don’t know what will actually help COVID 100%, in terms of supplements because there’s no studies and they won’t make the studies, right? They’re doing studies on drugs and so there are some, you know, positive studies on some drugs, but there’s no study done on zinc, as far as I’m aware, yet. ٹھیک ہے؟ Maybe they use it as part of a combination or something.

But essentially, we’re not gonna get these studies on natural stuff and we should… Just like, we don’t really… And if we do, it’s gonna be a small study. Everyone’s gonna criticize it or whatever. But we kind of are used to that for a lot of other things also. We get small studies, but there’s no generally huge trials that are replicated three times, you know, and it’s, like, published in the best journals, right? We don’t really get that just because they don’t have the funding. But what we do see is that, you know, we do know that, let’s say, zinc could be beneficial and we do know that it can counteract some of these genetic variants. And we will prioritize that more if we see that there’s a good fit between zinc and the negative variants that you have. So, I do think that this is something…just like we see that you can be healthier and it’ll lower your risk. So the healthier you are, you know, before you get it, that’s obviously ideal. When you get it, it gets a little more gray.

But still, if you’re doing things that can help you lower inflammation, I personally think that should help. ٹھیک ہے؟ You know, and then if you already have respiratory distress, then that’s too late, pretty much, right? You don’t even have control of your health anymore because, generally, you’ll be on a ventilator. So you always wanna do prevention rather than a treatment. That’s always ideal. And especially when it comes to respiratory infections, you want your body to be in top shape. And what we give you recommendations basically to show you, here’s number one, how to make your body in top shape with your genes, taking your genes into account, also in a prioritized way. And also that if you do get it, hopefully, it’ll lower inflammatory cytokines that you’re at risk for. And hopefully, that will, you know, lower some risk in some way. But in that regard, there’s no clinical trials, let’s say, generally speaking.

Katie: Yeah, absolutely. And I think at the end of the day, I 100% agree with you that prevention works so much better than having to mitigate these things once you’re already having any kind of active problem, whether it be an infection or some kind of other chronic inflammatory disease. And I think understanding our genetics in a deeper way gives us the ability, like you’re saying, to be proactive about that and to do the things that can hopefully avoid the problems in the long-term. And especially with things like COVID, which just seems so confounding, like you said, because some people have shown no symptoms at all and then some people get very, very ill.

These are potentially clues that help us figure out, like which way people are more likely to go and help people mitigate those things. So I feel like long-term, this may be also a hope in being able to decide and know who can safely go out and still maintain normal life, and who needs to take more steps, to be a little bit more proactive. And I think that the same lesson applies to so many other aspects of health, longevity, and genes. Because just like with COVID, some people can get it and be asymptomatic, and handle it just fine. I feel like even with other genetic reasons, people might be predisposed to something and still never struggle with it or never get it. And that’s where, like, the lifestyle factors come in. So I’d love to go a little deeper on a couple other genes and just learned about them, somewhat selfishly related to my own, but also because they’re ones that seem to be relatively common. And one that came up for me was PEMT, which seems to have a connection to fatty liver. Can you kind of give us an overview of what that is and what that means?

Joe: Yeah, before I go into PEMT, I think you brought up a really great point in terms of a genetic risk versus, like, general risk, right? And so one thing that’s really important to know about these things is that you can have a high genetic risk and a low actual risk, right? And in that sense, researchers are having a hard time predicting based on genetics what you will get, right? Because it has to do with so many different factors that are not genetics. And there’s many ways to counteract your genetic variants that you might be doing unconsciously, but you’re living healthy or whatever. ٹھیک ہے؟ So it’s very important to understand the difference between genetic risk and just general risk.

And so let’s say if we get to something like COVID or some kind of other respiratory infection…and by the way, respiratory infections are one of the top killers in the U.S., for sure, and probably the world, definitely the developed world, right? And COVID is just like another one of them, right? So it’s just making it worse, but it was already one of the top killers. So respiratory infections and infections, in general, are a very important topic. But when we’re talking about risk, it’s very hard to predict, you know, based on your genes, whether you’re going to get COVID, whether you’re going to, you know, have complications from it or whether you’re gonna be hospitalized with it. That’s why we actually created another tool that’s kind of a companion to it, which we look at certain kinds of data, like, you know, for example, what are your underlying preconditions?

You know, we’re looking basically…like, what’s your age? We’re looking at a bunch of different data that is more predictive, right? So if someone has a condition, you know, like, let’s say if somebody already has diabetes, then that’s actually more predictive than any other genes that you might have because we know that this person is unhealthy, right? And so that’s why we kind of… When it comes to genetic risk, you have to be careful that it’s just saying, you know, you maybe have a higher genetic risk, but it doesn’t actually tell you your absolute risk, which is why we have that tool to tell you here’s your factors that we can see, right, visible factors, here is your risk for hospitalization. Here is your risk of death.” And things like that. But then you always see, like, some kind of weird case where somebody looks healthy and they have complications. That’s more genetics, number one. And two, they’re probably not that healthy, they just don’t have any diagnosable condition. ٹھیک ہے؟ So I wanted to get that out of the way of genetic risk versus general risk. Now you wanted to look at PEMT, now, number one is, PEMT… So first of all, like, I said, it’s PEMT… I’m assuming you’re interested in metabolic health with regard to PEMT?

Katie: Yeah. And also the liver connection. I know fatty liver is a big topic right now. I’m seeing it more and more in the research.

Joe: Okay. So what I see, for example, is… Yeah, so let’s say, PEMT is associated with fatty liver. And when we looked at the metabolic section, you were able to see that that was the first gene that came up in terms of… We haven’t done a very… That’s probably the least extensive section out of all the categories we have. Like, for example, right now we’re very focused on gut inflammation. And, you know, let’s say, before that, we were very focused on COVID and respiratory infection, so we really went hard on that. But let’s say for the metabolic section, just for the genes that we’re looking at, we see that PEMT, you know, is… So let’s say, for example…here’s a way to think about this.

You can actually check if you have fatty liver, right? I actually got checked if I had fatty liver just for the heck of it. And it turns out that I don’t have any fatty liver, the size of my liver is perfect. It was I think 14 centimeters if I could recall. But essentially, you can check. They can do an ultrasound and see the size of your liver. I don’t know if they do it as, you know… I actually did it in India, so I don’t know if they do it, like, in the U.S. or whatever. But essentially, even if you can’t check for it, there are other ways of knowing. Like, for example, if you’re overweight, then it’s more likely that you have fatty liver, much more likely.

But really, like, the best way would obviously just be to check, if you have fatty liver, what’s the size of your liver? So let’s say if you told me, like, “Okay, I got checked for fatty liver or I have a lot of things that would make me believe I have fatty liver. I have these risk factors.” Now, we say, “Okay, if you already have fatty liver,” and especially if you’re trying to be healthy… If you’re not trying to be healthy then, you know, it’s just like, okay, there’s gonna be genes, right, because there’s people who don’t eat healthy and they don’t have as fatty of a liver as some other people, right? There is a variation in how fatty the liver is, within the population of people who are eating unhealthy. So there’s definitely a genetic component, but there’s obviously a very strong lifestyle component.

But let’s say there are always outliers in all these examples, right? There’s people who could be doing a lot of things well and then they still maybe have fatty liver. It’s generally pretty rare, but it does happen. And that’s where especially, especially, especially you wanna look at the genes, right? So you already know, let’s say if, or you already suspect that you have fatty liver, what are the genes that are putting me at risk for this? Because there has to be genes and so like you did, you went to the category section and automatically categorized the genes that were putting you most at risk. And so if we look at PEMT, right, this basically is very important for methylation and choline, right?

And so it’s thought that a lot of the negative effects from these PEMT variations are as a result of lower choline. And we know that having a higher level of choline intake can help liver health. And so when it comes to, let’s say, this PEMT gene, I haven’t looked at it, in particularly, but let’s say if I just scroll to the recommendations, it’s basically giving recommendations like I would have thought. It’s basically saying if low PEMT activity impairs choline production, so then you should make sure you’re getting enough from your diet to compensate. And then it tells you things like beef, liver, eggs, chicken, cod-fish, shiitake mushrooms, these are sources of choline. And then it shows us the supplement section that…choline supplements. It gives a bunch of choline supplements.

And then it also shows that, you know, estrogens, even plant-derived estrogens, they can help increase PEMT, they basically boost PEMT production. And so these are some good ways, for example, to counteract this specific gene. Are you getting…? You know, so if you check your liver, especially, or if you have risk factors, it could be very high cholesterol is a risk factor for fatty liver, being overweight, diabetes, that’s for sure. you know, having high blood sugar, high fasting blood sugar is a really good way. Triglycerides, in particular, would be a very good way to estimate if you have, you know, fatty liver and whatnot.

And so let’s say you either directly check or you assume that based on, you know, what I just told you, you probably have fatty liver or whatever, then you wanna make sure that you’re doing these things, that you’re consuming enough choline, then maybe you’re increasing some plant compounds that can increase PEMT, that are generally healthy anyway for a fatty liver. And a good example of that could be green tea, right? So, green tea is associated with liver health and it reduced liver enzymes in 80 people with fatty liver disease. It also has some estrogenic potential to it. And so green tea is like a good generally healthy way of counteracting the PEMT and also increasing your choline. And again, if you just had the PEMT gene and you didn’t have fatty liver, you didn’t have any of the risk factors for it, like I said, your triglycerides are low, your fasting blood sugar was very great, then it’s not something you need to worry about because you’re probably living a healthy lifestyle, that it’s not coming into play even.

Katie: Gotcha. Yeah, that’s super fascinating. And, like, I was reading through this…it’s interesting because I know I’ve done the liver test as well. My liver is fine and I have really normal fasting glucose and my triglycerides are normal. But in reading this, I do have to avoid eggs because I’m intolerant to them and I typically have too high of iron so I don’t eat much red meat, especially liver. And so I did start supplementing with choline recently and noticed a huge difference just in how I felt. So this was helpful to know that there’s a higher likelihood of deficiency of choline with this, which I’ve kind of found by experimentation, but it’s so helpful to see it kind of laid out along with what other supplements can be really helpful.

And I think it’s so fascinating to get to go through these reports and kind of figure out and prioritize based on symptoms and have the ability to input all that data together.

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For anyone who’s not familiar, who has not done genetic testing before, kind of walk us through what that process looks like. I know that there’s a link in the show notes at wellnessmama.fm for anybody who wants to run these reports and be able to see all of this data for themselves, but kind of walk us through the process.

Joe: Yeah. So I just wanna touch on one thing that you said, in particular, because I think it was an amazing example of something I spoke about before. So the first thing that comes up is diet, let’s say. And you see, beef, liver, eggs, you know, and like those are two great sources of choline. But for you, you already know that they’re not meant for you because you’re sensitive to eggs, I’m sensitive to eggs as well, and you’re trying to lower your iron or whatever, so you have other data points that you’re looking at. And this is what I was kind of saying before, that’s one way to prioritize. But you’re not gonna do these things if you already know that there’s other reasons you don’t wanna do that.

And so you go to the supplement section and it says choline, right, “Take these kinds of choline.” And that’s essentially what you did, right? So I think the way you did it is not… You don’t wanna read it and be like, “I gotta take beef, liver. It’s telling me I gotta do it,” right? You also wanna, you know, use some common sense and use your general knowledge of your body in other ways to, you know, guide you in that process. And if you don’t feel like you can do it, you can, you know, work with a coach or someone else. But essentially, you want this information, you also wanna look at it in a holistic way. To answer your question, in terms of the genetic process, how somebody would get started in this. Basically, you have to, number one, have your genetic file. And, you know, there’s a question, do you wanna get the whole genome or not?

Right now getting a snip chip or a whole genome, the whole genome is not gonna offer any additional benefit than getting a snip chip that… A snip chip is basically like a partial sequencing of your genomes, things that 23andMe and Ancestry do. ٹھیک ہے؟ And so, we do the same thing. The reason why we offer a chip is number one is it’s a bit better than 23andMe and significantly better than Ancestry. That’s number one. And also it integrates better, of course, right? These other companies are often trying to not allow you… You know, they’re making it harder, basically, to upload your stuff to other companies. So, we allow you to, you know, just buy it, you know, use the swab, send it back, and then it’s automatically uploaded. So, it’s a bit easier.

But in addition, a lot of people are very insecure about their data privacy. That’s the number one issue that we have. And it’s actually a very important issue. And so, first of all, you know, our whole team is very aware and very concerned about data privacy. And, you know, it’s not part of our model to sell data to pharmaceutical companies like 23andMe or Ancestry. The thing is that even if you didn’t trust us, generally, small companies, I mean, not generally, small companies can not do what 23andMe is doing. You basically have to have 10 million genomes in order to sell to a pharmaceutical company or, you know, in the millions, right? We’re a boutique, you know, genetics company that is…

We don’t have 10 million genomes, even if we wanted to sell it, we would. And again, we’re very, very against that. So, that’s the other reason why we offer our own chip for people worried about genetic privacy. So, you know, if you want a slightly better chip or you’re worried about genetic privacy or you want a more convenient approach, you’re able to buy through us and it’s the same price as 23andMe and Ancestry. If you already have a file from 23andMe or Ancestry, you don’t need to buy our file and you just upload it, right? So you sign up, you upload it.

And basically, the model that we have is a subscription model. And we have a cheap price so that people can afford it, right? So right now it’s, $59 a year and it’s gonna go up when we add the lab test to it, which is soon. But essentially, the reason why we have it based on the year is because we’re always coming out with new science, new reports, new blog posts, new risk assessments, new lab assessments, and a bunch of new information that you can constantly keep up to date with, right? It’s like you can almost… We’re making it so that you can use it daily and so that, like, you can read the blog daily and see, you know, what’s the new information coming up, whether it’s about COVID or respiratory infections, or it’s about, you know, some other issue that maybe came up, or you just got your lab test done. So with our personalized blog, which is what we were looking at, right, it’s basically we have blog posts coming out very often, right, and you’re able to read that like pretty much every day and look at the…

It’s all personalized. Instead of something that’s not personalized, it’s very personalized for each person. So the content actually changes…the recommendations, the content, the risk phases that you get, they all change based on your genetic variations. And so basically somebody would…number one, they have their file, they upload it. If they don’t wanna… You know, they could download a couple of reports, get some recommendations about the topics that they’re interested in. I always recommend, you know, what are you interested in? If you wanna improve cognitive function, we have that. If you wanna improve longevity, we have that. These are kinds of things if you don’t have a problem, right?

If you have some kind of problem or you’re very concerned about something, it could be respiratory infections, we recommend looking at that specific thing and that specific report, and following the recommendations there, assuming it fits in with your general understanding of what’s good for you. ٹھیک ہے؟ And then the other thing is the blog, which is really important. You can look at the specific genes. The report does include information, but the blog is way more comprehensive. And so you could categorize based on, “Here’s the category I want.” So let’s say you looked at metabolic health…I’m interested in metabolic health. And then it shows you which are the posts that are most important for you. And PEMT came up first and it turns out that it is probably the most important for you, definitely from the posts that we have, the genes that we have.

And so then you look at that and you look at the recommendations. And so, that’s essentially how an individual… And then we also have this, you know, genetic symptoms and conditions analyzer where an individual…let’s say, if we don’t have the topic, they can look at snips in some area and…you know, it just requires some more digging from themselves. But we have this whole platform that allows people to dig in in different ways. ٹھیک ہے؟ But the report and the blogs are much more hand-fed, whereas the rest of the platform, you know, you have to, like, put some time into it. But that’s also very helpful, right? You could, like, look up any topic and they’ll show you what the snips are, that are related to it. So essentially that’s how… And then an individual can cancel at any time if they don’t wanna be on the subscription. And so that’s essentially how an individual would get started in this.

Katie: I love it. And like I said, I’ll make sure that there are links in the show notes, people can find all of that. I know that there’s also a discount code that you guys have offered and that will be in the show notes as well. I think we’ll have to do a round two one day as well because I think this topic, truly we could do a dozen episodes. There’s just so much information and more coming out all the time. Like you said, you guys have new reports all the time. I just was excited to get you on to talk about the genetic risk factors when it comes to respiratory disease because that’s so top of mind right now.

And it really is helpful to see, like in my own data and I’m curious to do it with my husband, and my kids’ data as well, what those risk factors are and ways that we can support the body, and kind of understand all of our own risks, as we navigate this whole chaos right now. So, Joe, I’m just so grateful that you are here and that you’ve shared all of this. I definitely would encourage any of you guys who are interested to check out the links in the show notes, wellnessmama.fm. And I’ll still post those on social if you are listening when this first comes out. But, Joe, thanks so much. This is so fascinating. Like I said, I think it’s a topic we’re gonna just continue to learn more and more about.

Joe: Thank you so much for having me. It was definitely a pleasure.

Katie: And thanks as always to all of you for listening, sharing your most valuable asset, your time, with us today. We’re so grateful that you did, and I hope that you will join me again on the next episode of “The Wellness Mama Podcast.”

If you’re enjoying these interviews, would you please take two minutes to leave a rating or review on iTunes for me? Doing this helps more people to find the podcast, which means even more moms and families could benefit from the information. I really appreciate your time, and thanks as always for listening.



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